Cholinergic deficiency involved in vascular dementia: possible mechanism and strategy of treatment
文献类型：期刊论文
| 作者 | Wang, Juan; Zhang, Hai-yan ; Tang, Xi-can
|
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 2009-07 |
| 卷号 | 30期号:7页码:879-888 |
| 关键词 | vascular dementia cholinergic deficit acetylcholinesterase inhibitor inflammation |
| ISSN号 | 1671-4083 |
| DOI | 10.1038/aps.2009.82 |
| 文献子类 | Review |
| 英文摘要 | Vascular dementia (VaD) is a progressive neurodegenerative disease with a high prevalence. Several studies have recently reported that VaD patients present cholinergic deficits in the brain and cerebrospinal fluid (CSF) that may be closely related to the pathophysiology of cognitive impairment. Moreover, cholinergic therapies have shown promising effects on cognitive improvement in VaD patients. The precise mechanisms of these cholinergic agents are currently not fully understood; however, accumulating evidence indicates that these drugs may act through the cholinergic anti-inflammatory pathway, in which the efferent vagus nerve signals suppress pro-inflammatory cytokine release and inhibit inflammation, although regulation of oxidative stress and energy metabolism, alleviation of apoptosis may also be involved. In this paper, we provide a brief overview of the cholinergic treatment strategy for VaD and its relevant mechanisms of anti-inflammation. |
| WOS关键词 | NICOTINIC ACETYLCHOLINE-RECEPTORS ; SPONTANEOUSLY HYPERTENSIVE-RATS ; CHRONIC CEREBRAL HYPOPERFUSION ; ATTENUATES COGNITIVE DEFICITS ; L-ALPHA-GLYCERYLPHOSPHORYLCHOLINE ; ALZHEIMERS-DISEASE PATIENTS ; OXYGEN-GLUCOSE DEPRIVATION ; TRANSIENT GLOBAL-ISCHEMIA ; HUPERZINE-A ; DOUBLE-BLIND |
| 资助项目 | Ministry of Science and Technology of China[2004CB518907] ; National Natural Science Foundation of China[30801402] ; Knowledge Innovation Program of the Chinese Academy of Sciences[SIMM0709QN-2] |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| CSCD记录号 | CSCD:3628661 |
| WOS记录号 | WOS:000268066400001 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279188]  |
| 专题 | 院士及顾问专家 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Tang, Xi-can |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Juan,Zhang, Hai-yan,Tang, Xi-can. Cholinergic deficiency involved in vascular dementia: possible mechanism and strategy of treatment[J]. ACTA PHARMACOLOGICA SINICA,2009,30(7):879-888. |
| APA | Wang, Juan,Zhang, Hai-yan,&Tang, Xi-can.(2009).Cholinergic deficiency involved in vascular dementia: possible mechanism and strategy of treatment.ACTA PHARMACOLOGICA SINICA,30(7),879-888. |
| MLA | Wang, Juan,et al."Cholinergic deficiency involved in vascular dementia: possible mechanism and strategy of treatment".ACTA PHARMACOLOGICA SINICA 30.7(2009):879-888. |
入库方式： OAI收割
来源：上海药物研究所
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