[6]-Gingerol Suppresses Colon Cancer Growth by Targeting Leukotriene A(4) Hydrolase
文献类型：期刊论文
| 作者 | Jeong, Chul-Ho2; Bode, Ann M.2; Pugliese, Angelo2; Cho, Yong-Yeon2; Kim, Hong-Gyum2; Shim, Jung-Hyun2; Jeon, Young-Jin2,3; Li, Honglin1,4; Jiang, Hualiang1,4 ; Dong, Zigang2
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| 刊名 | CANCER RESEARCH
 |
| 出版日期 | 2009-07-01 |
| 卷号 | 69期号:13页码:5584-5591 |
| ISSN号 | 0008-5472 |
| DOI | 10.1158/0008-5472.CAN-09-0491 |
| 文献子类 | Article |
| 英文摘要 | [6]-Gingerol, a natural component of ginger, exhibits anti-inflammatory and antitumorigenic activities. Despite its potential efficacy in cancer, the mechanism by which [6]-gingerol exerts its chemopreventive effects remains elusive. The leukotriene A(4) hydrolase (LTA(4)H) protein is regarded as a relevant target for cancer therapy. Our in silico prediction using a reverse-docking approach revealed that LTA(4)H might be a potential target of [6]-gingerol. We supported our prediction by showing that [6]-gingerol suppresses anchorage-independent cancer cell growth by inhibiting LTA(4)H activity in HCT116 colorectal cancer cells. We showed that [6]-gingerol effectively suppressed tumor growth in vivo in nude mice, an effect that was mediated by inhibition of LTA(4)H activity. Collectively, these findings indicate a crucial role of LTA(4)H in cancer and also support the anticancer efficacy of [6]-gingerol targeting of LTA(4)H for the prevention of colorectal cancer. [Cancer Res 2009;69(13):5584-91] |
| WOS关键词 | NF-KAPPA-B ; INFLAMMATORY RESPONSES ; IN-VIVO ; INHIBITORS ; MICE ; CHEMOPREVENTION ; EXPRESSION ; BESTATIN ; DOCKING ; ENZYME |
| 资助项目 | Hormel Foundation[00000000] ; Pediatric Pharmaceuticals[00000000] ; Korea Research Foundation[KRF-2007-357-C00084] ; 863 Hi-Tech Program of China[2007AA02Z304] ; Shanghai Committee of Science and Technology[07dz22004] |
| WOS研究方向 | Oncology |
| 语种 | 英语 |
| WOS记录号 | WOS:000267691800041 |
| 出版者 | AMER ASSOC CANCER RESEARCH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279195]  |
| 专题 | 药物发现与设计中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Dong, Zigang |
| 作者单位 | 1.Chinese Acad Sci, Drug Discovery & Design Ctr, State Key Lab Drug Res, Shanghai Inst Mat Med, Beijing 100864, Peoples R China; 2.Univ Minnesota, Hormel Inst, Austin, MN 55912 USA; 3.Chosun Univ, Coll Med, Dept Pharmacol, Gwanju, South Korea; 4.E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jeong, Chul-Ho,Bode, Ann M.,Pugliese, Angelo,et al. [6]-Gingerol Suppresses Colon Cancer Growth by Targeting Leukotriene A(4) Hydrolase[J]. CANCER RESEARCH,2009,69(13):5584-5591. |
| APA | Jeong, Chul-Ho.,Bode, Ann M..,Pugliese, Angelo.,Cho, Yong-Yeon.,Kim, Hong-Gyum.,...&Dong, Zigang.(2009).[6]-Gingerol Suppresses Colon Cancer Growth by Targeting Leukotriene A(4) Hydrolase.CANCER RESEARCH,69(13),5584-5591. |
| MLA | Jeong, Chul-Ho,et al."[6]-Gingerol Suppresses Colon Cancer Growth by Targeting Leukotriene A(4) Hydrolase".CANCER RESEARCH 69.13(2009):5584-5591. |
入库方式： OAI收割
来源：上海药物研究所
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