Huperzine A protects isolated rat brain mitochondria against beta-amyloid peptide
文献类型：期刊论文
| 作者 | Gao, Xin; Zheng, Chun Yan; Yang, Ling; Tang, Xi Can; Zhang, Hai Yan |
| 刊名 | FREE RADICAL BIOLOGY AND MEDICINE
 |
| 出版日期 | 2009-06-01 |
| 卷号 | 46期号:11页码:1454-1462 |
| 关键词 | Huperzine A beta-Amyloid peptide Mitochondria Oxidative phosphorylation Free radicals |
| ISSN号 | 0891-5849 |
| DOI | 10.1016/j.freeradbiomed.2009.02.028 |
| 文献子类 | Article |
| 英文摘要 | Our previous work in cells and animals showed that mitochondria are involved in the neuroprotective effect of huperzine A (HupA). In this study, the effects of HupA on isolated rat brain mitochondria were investigated. In addition to inhibiting the A beta(25-35) (40 mu M)-induced decrease in mitochondrial respiration, adenosine 5'-triphosphate (ATP) synthesis, enzyme activity, and transmembrane potential, HupA (0.01 or 0.1 mu M) effectively prevented A beta-induced mitochondrial swelling, reactive oxygen species increase, and cytochrome c release. More interestingly, administration of HupA to isolated mitochondria promoted the rate of ATP production and blocked mitochondrial swelling caused by normal osmosis. These results indicate that HupA protects mitochondria against A beta at least in part by preserving membrane integrity and improving energy metabolism. These direct effects on mitochondria further extend the noncholinergic functions of HupA. (C) 2009 Elsevier Inc. All rights reserved. |
| WOS关键词 | PERMEABILITY TRANSITION PORE ; ALPHA-KETOGLUTARATE DEHYDROGENASE ; NATURAL CHOLINESTERASE INHIBITOR ; CYTOCHROME-C RELEASE ; ALZHEIMERS-DISEASE ; LIVER-MITOCHONDRIA ; OXIDATIVE STRESS ; HYDROGEN-PEROXIDE ; FREE-RADICALS ; A-BETA |
| 资助项目 | National Science Foundation of China[30801402] ; National Science Foundation of China[30572169] ; Ministry of Science and Technology of China[2004CB518907] ; Chinese Academy of Sciences[SIMM0709QN-12] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Endocrinology & Metabolism |
| 语种 | 英语 |
| WOS记录号 | WOS:000265970400002 |
| 出版者 | ELSEVIER SCIENCE INC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279226]  |
| 专题 | 院士及顾问专家 中科院受体结构与功能重点实验室 新药研究国家重点实验室 药理学第二研究室 |
| 通讯作者 | Tang, Xi Can |
| 作者单位 | Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gao, Xin,Zheng, Chun Yan,Yang, Ling,et al. Huperzine A protects isolated rat brain mitochondria against beta-amyloid peptide[J]. FREE RADICAL BIOLOGY AND MEDICINE,2009,46(11):1454-1462. |
| APA | Gao, Xin,Zheng, Chun Yan,Yang, Ling,Tang, Xi Can,&Zhang, Hai Yan.(2009).Huperzine A protects isolated rat brain mitochondria against beta-amyloid peptide.FREE RADICAL BIOLOGY AND MEDICINE,46(11),1454-1462. |
| MLA | Gao, Xin,et al."Huperzine A protects isolated rat brain mitochondria against beta-amyloid peptide".FREE RADICAL BIOLOGY AND MEDICINE 46.11(2009):1454-1462. |
入库方式： OAI收割
来源：上海药物研究所
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