Highly Diastereoselective Conjugate Addition-Elimination of Chiral Nickel(II) Glycinate with Activated Allylic Acetates for Asymmetric Synthesis of Glutamic Acid Derivatives
文献类型：期刊论文
| 作者 | Wang, Jiang ; Shi, Jianmei; Zhang, Xiaodong; Lin, Daizong; Jiang, Hualiang; Liu, Hong
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| 刊名 | SYNTHESIS-STUTTGART
 |
| 出版日期 | 2009-05-18 |
| 期号 | 10页码:1744-1752 |
| 关键词 | nickel(II) complex asymmetric synthesis glutamic acid amino acids |
| ISSN号 | 0039-7881 |
| DOI | 10.1055/s-0028-1088075 |
| 文献子类 | Article |
| 英文摘要 | A practically feasible, diastereoselective conjugate addition-elimination reaction of a chiral nickel(II) complex of glycine I with allylic acetates 2 is described. The reaction pathway was successfully controlled, and the desired formation of a carbon-carbon bond was exclusively obtained with high diastereoselectivity. This reaction is an attractive route for the asymmetric synthesis of previously unavailable chainlike glutamic acid derivatives. |
| WOS关键词 | ALPHA-AMINO-ACIDS ; X-RAY CRYSTAL ; GENERAL-METHOD ; FACE DIASTEREOSELECTIVITY ; MOLECULAR-STRUCTURE ; ENANTIOSELECTIVE SYNTHESIS ; OPERATIONALLY CONVENIENT ; ALKYLBENZYL BROMIDES ; NUCLEOPHILIC GLYCINE ; PYROGLUTAMIC ACIDS |
| 资助项目 | National Natural Science Foundation of China[20721003] ; National Natural Science Foundation of China[20872153] ; International Collaboration Projects[2007DFB30370] ; International Collaboration Projects[20720102040] ; 863 Hi-Tech Program of China[2006AA020602] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000266382800023 |
| 出版者 | GEORG THIEME VERLAG KG |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279236]  |
| 专题 | 药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Liu, Hong |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, State Key Lab Drug Res,Ctr Drug Discovery & Desig, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Jiang,Shi, Jianmei,Zhang, Xiaodong,et al. Highly Diastereoselective Conjugate Addition-Elimination of Chiral Nickel(II) Glycinate with Activated Allylic Acetates for Asymmetric Synthesis of Glutamic Acid Derivatives[J]. SYNTHESIS-STUTTGART,2009(10):1744-1752. |
| APA | Wang, Jiang,Shi, Jianmei,Zhang, Xiaodong,Lin, Daizong,Jiang, Hualiang,&Liu, Hong.(2009).Highly Diastereoselective Conjugate Addition-Elimination of Chiral Nickel(II) Glycinate with Activated Allylic Acetates for Asymmetric Synthesis of Glutamic Acid Derivatives.SYNTHESIS-STUTTGART(10),1744-1752. |
| MLA | Wang, Jiang,et al."Highly Diastereoselective Conjugate Addition-Elimination of Chiral Nickel(II) Glycinate with Activated Allylic Acetates for Asymmetric Synthesis of Glutamic Acid Derivatives".SYNTHESIS-STUTTGART .10(2009):1744-1752. |
入库方式： OAI收割
来源：上海药物研究所
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