PSD-95 regulates D-1 dopamine receptor resensitization, but not receptor-mediated Gs-protein activation
文献类型：期刊论文
| 作者 | Sun, Peihua2; Wang, Jingru2; Gu, Weihua2; Cheng, Wei1; Jin, Guo-zhang2 ; Friedman, Eitan3; Zheng, Jie1; Zhen, Xuechu2
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| 刊名 | CELL RESEARCH
 |
| 出版日期 | 2009-05 |
| 卷号 | 19期号:5页码:612-624 |
| 关键词 | PSD-95 dopamine receptor Gs-protein activation desensitization recycling resensitization |
| ISSN号 | 1001-0602 |
| DOI | 10.1038/cr.2009.30 |
| 文献子类 | Article |
| 英文摘要 | The present study aims to define the role of postsynaptic density (PSD)-95 in the regulation of dopamine (DA) receptor function. We found that PSD-95 physically associates with either D-1 or D-2 DA receptors in co-transfected HEK-293 cells. Stimulation of DA receptors altered the association between D-1 receptor and PSD-95 in a time-dependent manner. Functional assays indicated that PSD-95 co-expression did not affect D-1 receptor-stimulated cAMP production, Gs-protein activation or receptor desensitization. However, PSD-95 accelerated the recovery of internalized membrane receptors by promoting receptor recycling, thus resulting in enhanced resensitization of internalized D1 receptors. Our results provide a novel mechanism for regulating DA receptor recycling that may play an important role in postsynaptic DA functional modulation and synaptic neuroplasticity. |
| WOS关键词 | AGONIST-INDUCED DESENSITIZATION ; ADENYLYL-CYCLASE ACTIVITY ; PDZ DOMAIN PROTEINS ; NMDA RECEPTOR ; POSTSYNAPTIC DENSITY ; D1 RECEPTOR ; MOLECULAR-MECHANISMS ; GUANYLATE KINASES ; STRIATAL NEURONS ; INTERNALIZATION |
| 资助项目 | Natural Science Foundation of China[30770662] ; Natural Science Foundation of China[30825042] ; Hi-Tech Research and Development Program of China[2007AA02Z163] ; National Basic Research Program[2009CB2200] ; National Institutes of Health[REY016754A] ; American Heart Association[0665201Y] ; National Center for Research Resources[C06-RR-12088-01] |
| WOS研究方向 | Cell Biology |
| 语种 | 英语 |
| CSCD记录号 | CSCD:3614680 |
| WOS记录号 | WOS:000266527600010 |
| 出版者 | INST BIOCHEMISTRY & CELL BIOLOGY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279247]  |
| 专题 | 药理学第二研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Zhen, Xuechu |
| 作者单位 | 1.Univ Calif Davis, Dept Physiol & Membrane Biol, Sch Med, Davis, CA 95616 USA; 2.Chinese Acad Sci, Dept Neuropharmacol, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 3.CUNY Med Sch CCNY, Dept Physiol & Pharmacol, New York, NY USA |
| 推荐引用方式 GB/T 7714 | Sun, Peihua,Wang, Jingru,Gu, Weihua,et al. PSD-95 regulates D-1 dopamine receptor resensitization, but not receptor-mediated Gs-protein activation[J]. CELL RESEARCH,2009,19(5):612-624. |
| APA | Sun, Peihua.,Wang, Jingru.,Gu, Weihua.,Cheng, Wei.,Jin, Guo-zhang.,...&Zhen, Xuechu.(2009).PSD-95 regulates D-1 dopamine receptor resensitization, but not receptor-mediated Gs-protein activation.CELL RESEARCH,19(5),612-624. |
| MLA | Sun, Peihua,et al."PSD-95 regulates D-1 dopamine receptor resensitization, but not receptor-mediated Gs-protein activation".CELL RESEARCH 19.5(2009):612-624. |
入库方式： OAI收割
来源：上海药物研究所
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