Design, synthesis and anti-HBV activity of novel bis(trifluoroethyl)phosphonomethyl ether derivatives of acyclovir
文献类型：期刊论文
| 作者 | Lu, Peng2; Jiang, Sai Hong2; Liu, Jiang Xia1; Yang, Yu She2; Ji, Ru Yun2 |
| 刊名 | CHINESE CHEMICAL LETTERS
 |
| 出版日期 | 2009-05 |
| 卷号 | 20期号:5页码:507-510 |
| 关键词 | Acyclovir Phosphonate Anti-HBV activity |
| ISSN号 | 1001-8417 |
| DOI | 10.1016/j.cclet.2008.12.057 |
| 文献子类 | Article |
| 英文摘要 | A series of novel bis(trifluoroethyl)phosphonomethyl ether derivatives of acyclovir was synthesized and their in vitro anti-HBV activity was evaluated in HepG2 2.2.15 cells. In contrast to acyclovir, most of the described phosphonates emerged as potent inhibitors of HBV replication. Especially, the most active compound 11 with IC50 value of 2.92 mu mol/L was 33 times more potent than acyclovir with IC50 value of 100 mu mol/L. (C) 2009 Yu She Yang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved. |
| WOS关键词 | IN-VITRO ; ANALOGS ; PURINE |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000266222400001 |
| 出版者 | ELSEVIER SCIENCE INC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279250]  |
| 专题 | 药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Yang, Yu She |
| 作者单位 | 1.Fudan Univ, Shanghai 200032, Peoples R China 2.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai Inst Biol Sci, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Lu, Peng,Jiang, Sai Hong,Liu, Jiang Xia,et al. Design, synthesis and anti-HBV activity of novel bis(trifluoroethyl)phosphonomethyl ether derivatives of acyclovir[J]. CHINESE CHEMICAL LETTERS,2009,20(5):507-510. |
| APA | Lu, Peng,Jiang, Sai Hong,Liu, Jiang Xia,Yang, Yu She,&Ji, Ru Yun.(2009).Design, synthesis and anti-HBV activity of novel bis(trifluoroethyl)phosphonomethyl ether derivatives of acyclovir.CHINESE CHEMICAL LETTERS,20(5),507-510. |
| MLA | Lu, Peng,et al."Design, synthesis and anti-HBV activity of novel bis(trifluoroethyl)phosphonomethyl ether derivatives of acyclovir".CHINESE CHEMICAL LETTERS 20.5(2009):507-510. |
入库方式： OAI收割
来源：上海药物研究所
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