Cucurbitane-Type Triterpenoids from the Stems of Cucumis melo
文献类型：期刊论文
| 作者 | Chen, Chuan; Qiang, Shigao; Lou, Liguang ; Zhao, Weimin
|
| 刊名 | JOURNAL OF NATURAL PRODUCTS
 |
| 出版日期 | 2009-05 |
| 卷号 | 72期号:5页码:824-829 |
| ISSN号 | 0163-3864 |
| DOI | 10.1021/np800692t |
| 文献子类 | Article |
| 英文摘要 | Phytochemical investigation of the stems of Cucumis melo led to the isolation and identification of 21 cucurbitane-type triterpenoids, including nine new compounds (1-9) and 12 known compounds. Their structures were determined on the basis of spectroscopic analyses, chemical methods, and comparison with spectroscopic data in the literature. Two known compounds, cucurbitacin B (10) and cucurbitacin A (11), showed significant cytotoxic activity against the proliferation of A549/ATCC and BEL7402 cells in vitro. Of the new compounds, only compound 7 was weakly cytotoxic. The inhibitory effects of all compounds on the Jak-Stat3 signaling pathway were evaluated, but only cucurbitacin B (10) showed significant inhibitory activity of phosphotyrosine STAT3. |
| WOS关键词 | POTENT ANTITUMOR-ACTIVITY ; TUMOR INHIBITORS ; MARAH-OREGANUS ; PRINCIPLES ; GLYCOSIDES ; PATHWAY ; CANCER |
| 资助项目 | Shanghai Institute of Materia Medica, Chinese Academy of Sciences[SIMM0709JC-11] |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000266389900004 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279257]  |
| 专题 | 药理学第一研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 天然药物化学研究室 |
| 通讯作者 | Lou, Liguang |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Chuan,Qiang, Shigao,Lou, Liguang,et al. Cucurbitane-Type Triterpenoids from the Stems of Cucumis melo[J]. JOURNAL OF NATURAL PRODUCTS,2009,72(5):824-829. |
| APA | Chen, Chuan,Qiang, Shigao,Lou, Liguang,&Zhao, Weimin.(2009).Cucurbitane-Type Triterpenoids from the Stems of Cucumis melo.JOURNAL OF NATURAL PRODUCTS,72(5),824-829. |
| MLA | Chen, Chuan,et al."Cucurbitane-Type Triterpenoids from the Stems of Cucumis melo".JOURNAL OF NATURAL PRODUCTS 72.5(2009):824-829. |
入库方式： OAI收割
来源：上海药物研究所
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