Cytotoxic Terpenoids from the Fruits of Vitex trifolia L.
文献类型：期刊论文
| 作者 | Wu, Jun; Zhou, Tong; Zhang, Shu-wei; Zhang, Xiao-hui; Xuan, Li-jiang
|
| 刊名 | PLANTA MEDICA
 |
| 出版日期 | 2009-03 |
| 卷号 | 75期号:4页码:367-370 |
| 关键词 | Vitex trifolia Verbenaceae fruits diterpenoids antiproliferation cell cycle |
| ISSN号 | 0032-0943 |
| DOI | 10.1055/s-0028-1112211 |
| 文献子类 | Article |
| 英文摘要 | Two new labdane-type diterpenoids vitetrifolin H (1) and vitetrifolin 1 (2), and one new monoterpenoid vitexoid (3), were isolated from the fruits of Vitex trifolia L., together with seven known diterpenoids. Structures of all compounds were elucidated by extensive spectroscopic methods. All these compounds exhibited inhibition of Hela cell proliferation, with IC50 values in the range of 4-28 mu M. In addition, vitetrifolin 1 (2) induced cell cycle G(0)/G(1) phase arrest and apoptosis of Hela cells. |
| WOS关键词 | DITERPENES ; APOPTOSIS |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:000264895100017 |
| 出版者 | GEORG THIEME VERLAG KG |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279308]  |
| 专题 | 上海中药现代化研究中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Xuan, Li-jiang |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Jun,Zhou, Tong,Zhang, Shu-wei,et al. Cytotoxic Terpenoids from the Fruits of Vitex trifolia L.[J]. PLANTA MEDICA,2009,75(4):367-370. |
| APA | Wu, Jun,Zhou, Tong,Zhang, Shu-wei,Zhang, Xiao-hui,&Xuan, Li-jiang.(2009).Cytotoxic Terpenoids from the Fruits of Vitex trifolia L..PLANTA MEDICA,75(4),367-370. |
| MLA | Wu, Jun,et al."Cytotoxic Terpenoids from the Fruits of Vitex trifolia L.".PLANTA MEDICA 75.4(2009):367-370. |
入库方式： OAI收割
来源：上海药物研究所
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