Harrisotones A-E, five novel prenylated polyketides with a rare spirocyclic skeleton from Harrisonia perforata
文献类型：期刊论文
| 作者 | Yin, Sheng; Chen, Xin; Su, Zu-Shang; Yang, Sheng-Ping; Fan, Cheng-Qi; Ding, Jian ; Yue, Jian-Min
|
| 刊名 | TETRAHEDRON
 |
| 出版日期 | 2009-02-07 |
| 卷号 | 65期号:6页码:1147-1152 |
| 关键词 | Harrisotones A-E Harrisonol A Cytotoxic activity Structural elucidation Harrisonia perforata |
| ISSN号 | 0040-4020 |
| DOI | 10.1016/j.tet.2008.11.068 |
| 文献子类 | Article |
| 英文摘要 | Five novel prenylated polyketides, harrisotones A-E (1-5) representing a rare spirocyclic skeleton, along with a new hydroperoxypolyketide harrisonol A (6), were isolated from the stems and leaves of Harrisonia perforata. The structures of harrisotones A-E (1-5) were extensively elucidated on the basis of spectroscopic analysis, especially 2D NMR and CD spectra. A plausible origin of compounds 1-5 was rationalized biogenetically, and traced back to harrisonol A (6). Harrisotones A-C (1-3) and harrisonol A (6) exhibited significant cytotoxicity against P-388 and/or A-549 tumor cell lines. (C) 2008 Elsevier Ltd. All rights reserved. |
| WOS关键词 | PHLOROGLUCINOL DERIVATIVES ; BIOSYNTHESIS ; LIMONOIDS ; APOPTOSIS |
| 资助项目 | National Natural Science Foundation[30630072] ; National Natural Science Foundation[30721005] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000263310100008 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279316]  |
| 专题 | 天然药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Yue, Jian-Min |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yin, Sheng,Chen, Xin,Su, Zu-Shang,et al. Harrisotones A-E, five novel prenylated polyketides with a rare spirocyclic skeleton from Harrisonia perforata[J]. TETRAHEDRON,2009,65(6):1147-1152. |
| APA | Yin, Sheng.,Chen, Xin.,Su, Zu-Shang.,Yang, Sheng-Ping.,Fan, Cheng-Qi.,...&Yue, Jian-Min.(2009).Harrisotones A-E, five novel prenylated polyketides with a rare spirocyclic skeleton from Harrisonia perforata.TETRAHEDRON,65(6),1147-1152. |
| MLA | Yin, Sheng,et al."Harrisotones A-E, five novel prenylated polyketides with a rare spirocyclic skeleton from Harrisonia perforata".TETRAHEDRON 65.6(2009):1147-1152. |
入库方式： OAI收割
来源：上海药物研究所
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