Gold-catalyzed intramolecular hydroamination of terminal alkynes in aqueous media: efficient and regioselective synthesis of indole-1-carboxamides
文献类型：期刊论文
| 作者 | Ye, Deju1; Wang, Jinfang1; Zhang, Xu1,2; Zhou, Yu1 ; Ding, Xiao1; Feng, Enguang1; Sun, Haifeng1; Liu, Guannan1; Jiang, Hualiang1; Liu, Hong1
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| 刊名 | GREEN CHEMISTRY
 |
| 出版日期 | 2009 |
| 卷号 | 11期号:8页码:1201-1208 |
| ISSN号 | 1463-9262 |
| DOI | 10.1039/b904044g |
| 文献子类 | Article |
| 英文摘要 | Using [Au(PPh(3))]Cl/Ag(2)CO(3)-catalyzed 5-endo-dig cyclization in water under microwave irradiation, we developed a fast and green route to prepare indole-1-carboxamides from N'-substituted N-(2-alkynylphenyl)ureas. The described method is tolerant to a variety of functional groups, including N'-aryl, alkyl, heterocyclic, various N-(substituted-2-ethynylphenyl) and N-(2-ethynylpyridin-3-yl) ureas and affords moderate to high yields of the desired products. |
| WOS关键词 | SILYL ENOL ETHERS ; MICROWAVE-ASSISTED SYNTHESIS ; ENDO-SELECTIVE CYCLIZATIONS ; INTERNAL ALKYNES ; INDOLE-DERIVATIVES ; ORGANIC-REACTIONS ; COUPLING REACTION ; 2,3-DISUBSTITUTED INDOLES ; BIMETALLIC CATALYST ; METAL VINYLIDENES |
| 资助项目 | National Natural Science Foundation of China[20721003] ; National Natural Science Foundation of China[20872153] ; International Collaboration Projects[2007DFB30370] ; International Collaboration Projects[20720102040] ; 863 Hi-Tech Program of China[2006AA020602] |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000268747700018 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279366]  |
| 专题 | 药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 药物发现与设计中心 |
| 通讯作者 | Ye, Deju |
| 作者单位 | 1.Chinese Acad Sci, Drug Discovery & Design Ctr, Shanghai Inst Mat Med, Shanghai Inst Biol Sci,State Key Lab Drug Res, Shanghai 201203, Peoples R China; 2.China Pharmaceut Univ, Dept Med Chem, Nanjing 210009, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ye, Deju,Wang, Jinfang,Zhang, Xu,et al. Gold-catalyzed intramolecular hydroamination of terminal alkynes in aqueous media: efficient and regioselective synthesis of indole-1-carboxamides[J]. GREEN CHEMISTRY,2009,11(8):1201-1208. |
| APA | Ye, Deju.,Wang, Jinfang.,Zhang, Xu.,Zhou, Yu.,Ding, Xiao.,...&Liu, Hong.(2009).Gold-catalyzed intramolecular hydroamination of terminal alkynes in aqueous media: efficient and regioselective synthesis of indole-1-carboxamides.GREEN CHEMISTRY,11(8),1201-1208. |
| MLA | Ye, Deju,et al."Gold-catalyzed intramolecular hydroamination of terminal alkynes in aqueous media: efficient and regioselective synthesis of indole-1-carboxamides".GREEN CHEMISTRY 11.8(2009):1201-1208. |
入库方式： OAI收割
来源：上海药物研究所
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