Anti-inflammatory effects of Z23 on LPS-induced inflammatory responses in RAW264.7 macrophages
文献类型：期刊论文
| 作者 | Hu, Xu-Dong2; Yang, Yang2; Zhong, Xiang-Gen3; Zhang, Xiang-Hua1; Zhang, Yi-Nan1; Zheng, Zong-Ping1; Zhou, Yu3 ; Tang, Wei3; Yang, Yi-Fu3; Hu, Li-Hong1
|
| 刊名 | JOURNAL OF ETHNOPHARMACOLOGY
 |
| 出版日期 | 2008-12-08 |
| 卷号 | 120期号:3页码:447-451 |
| 关键词 | Z23 Inducible nitric oxide synthase Cyclooxygenase2 Cytokine RAW264.7 macrophage |
| ISSN号 | 0378-8741 |
| DOI | 10.1016/j.jep.2008.09.026 |
| 文献子类 | Article |
| 英文摘要 | Aim of the study: Fissistigma oldhamii (Hemsl.) Merr, a traditional Chinese herb medicine, is used for treating rheumatoid arthritis in China. In our previous study, an effective compound, 7'-(3',4'-dihydroxyphenyl)-N-[(4-methoxyphenyl) ethyl] propenamide (Z23), from this herb has showed potent immunosuppressive effects both in vitro and in vivo. However, its anti-inflammatory effect and mechanism is still need to explore. Materials and methods: We examined the in vitro effects of Z23 on the production of nitric oxide (NO), prostaglandin E2 (PGE2) and cytokines by lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages. Results: Z23 significantly decreased the production of PGE2, NO, tumour necrosis factor alpha (TNFalpha) and 116 production. Inducible nitric oxide synthase (iNOS) and cyclooxygenase2 (COX2) gene expression were also significantly reduced. Conclusions: These results demonstrated that Z23 exerted an anti-inflammatory effect through modulating the synthesis of several mediators and cytokines involved in the inflammatory process. This study provided evidence to understand the therapeutic effects of Fissistigma oldhamii (Hemsl.) Merr and indicated that Z23 has the potential for treatment of various inflammatory diseases where the overproduction of NO, PGE2 and inflammatory cytokines has been shown to play a role, e.g. rheumatoid arthritis. (c) 2008 Elsevier Ireland Ltd. All rights reserved. |
| WOS关键词 | NITRIC-OXIDE SYNTHASE ; ALVEOLAR MACROPHAGES ; IN-VITRO ; INHIBITION ; EXPRESSION ; BIOSYNTHESIS ; CYTOKINE ; MICE ; VIVO |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:000261896500020 |
| 出版者 | ELSEVIER IRELAND LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279410]  |
| 专题 | 上海中药现代化研究中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 药理学第一研究室 |
| 通讯作者 | Hu, Li-Hong |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai 201203, Peoples R China; 2.Shanghai Univ Tradit Chinese Med, Chinese Acad Sci, Shanghai Inst Mat Med, Lab Immunol & Virol, Shanghai 201203, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hu, Xu-Dong,Yang, Yang,Zhong, Xiang-Gen,et al. Anti-inflammatory effects of Z23 on LPS-induced inflammatory responses in RAW264.7 macrophages[J]. JOURNAL OF ETHNOPHARMACOLOGY,2008,120(3):447-451. |
| APA | Hu, Xu-Dong.,Yang, Yang.,Zhong, Xiang-Gen.,Zhang, Xiang-Hua.,Zhang, Yi-Nan.,...&Zuo, Jian-Ping.(2008).Anti-inflammatory effects of Z23 on LPS-induced inflammatory responses in RAW264.7 macrophages.JOURNAL OF ETHNOPHARMACOLOGY,120(3),447-451. |
| MLA | Hu, Xu-Dong,et al."Anti-inflammatory effects of Z23 on LPS-induced inflammatory responses in RAW264.7 macrophages".JOURNAL OF ETHNOPHARMACOLOGY 120.3(2008):447-451. |
入库方式： OAI收割
来源：上海药物研究所
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