SYNTHESIS OF 2-SUBSTITUTED PYRIMIDO[5,4-b]INDOLIZINE DERIVATIVES FROM ACETATES OF BAYLIS-HILLMAN ADDUCTS
文献类型：期刊论文
| 作者 | Jiang, Min; He, Qian ; Yang, Chunhao; Xie, Yuyuan
|
| 刊名 | HETEROCYCLES
 |
| 出版日期 | 2008-11-01 |
| 卷号 | 75期号:11页码:2659-+ |
| 关键词 | Pyrimido[5,4-b]indolizine Baylis-Hillman Adduct Imidamide Hydrochloride 5-(Pyridin-2-ylmethyl)pyrimidin-4(3H)-one |
| ISSN号 | 0385-5414 |
| 文献子类 | Article |
| 英文摘要 | Novel tricyclic heterocycle pyrimido[5,4-b]indolizine derivatives 1 were synthesized conveniently in two steps. The key intermediates 2-substituted 5-[(pyridin-2-yl)methyl]pyrimidin-4(3H)-ones 2 were obtained by facile cyclization of the acetate of Baylis-Hillman adduct 3 and various amidine hydrochlorides 4 in the presence of sodium ethoxide. Treatment of 5-[(pyridin-2-yl)methyl]pyrimidin-4(3H)-ones 2 with phosphoryl chloride by reflux afforded fused 2-substituted pyrimido[5,4-b]indolizines 1 in high yield. |
| WOS关键词 | BIOLOGICAL EVALUATION ; INHIBITORS ; INDOLIZINE ; ALKALOIDS ; ANALOGS |
| 资助项目 | Innovation Program of the Chinese Academy of Sciences[KSCX2-YW-R-23] ; National Natural Science Foundation of China[20772138] ; National Natural Science Foundation of China[90713034] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000261352200003 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279451]  |
| 专题 | 药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Jiang, Min |
| 作者单位 | Chinese Acad Sci, SIBS, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jiang, Min,He, Qian,Yang, Chunhao,et al. SYNTHESIS OF 2-SUBSTITUTED PYRIMIDO[5,4-b]INDOLIZINE DERIVATIVES FROM ACETATES OF BAYLIS-HILLMAN ADDUCTS[J]. HETEROCYCLES,2008,75(11):2659-+. |
| APA | Jiang, Min,He, Qian,Yang, Chunhao,&Xie, Yuyuan.(2008).SYNTHESIS OF 2-SUBSTITUTED PYRIMIDO[5,4-b]INDOLIZINE DERIVATIVES FROM ACETATES OF BAYLIS-HILLMAN ADDUCTS.HETEROCYCLES,75(11),2659-+. |
| MLA | Jiang, Min,et al."SYNTHESIS OF 2-SUBSTITUTED PYRIMIDO[5,4-b]INDOLIZINE DERIVATIVES FROM ACETATES OF BAYLIS-HILLMAN ADDUCTS".HETEROCYCLES 75.11(2008):2659-+. |
入库方式： OAI收割
来源：上海药物研究所
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