Vascular Effects of Different Lipophilic Components of "Danshen", a Traditional Chinese Medicine, in the Isolated Porcine Coronary Artery
文献类型：期刊论文
| 作者 | Wan, Alan K. S.1; Leung, Susan W. S.1; Zhu, Da-Yuan2; Man, Ricky Y. K.1 |
| 刊名 | JOURNAL OF NATURAL PRODUCTS
 |
| 出版日期 | 2008-11 |
| 卷号 | 71期号:11页码:1825-1828 |
| ISSN号 | 0163-3864 |
| DOI | 10.1021/np800119k |
| 文献子类 | Article |
| 英文摘要 | "Danshen" has been used for the treatment of various cardiovascular diseases in the People's Republic of China for many years. Two different forms of "Danshen" exist, with the roots of Salvia miltiorrhiza being the traditional form and the roots of Salvia przewalskii being a surrogate used in the western areas of mainland China. The most abundant lipophilic diterpene quinones present in S. miltiorrhiza and S. przewalskii roots, tanshinone IIA (1) and cryptotanshinone (2), inhibited contraction of the isolated porcine coronary artery to the thromboxane A(2) analogue, U46619. Przewaquinone A (3), a lipophilic diterpene quinone present only in S. przewalskii, induced a similar but greater inhibitory action on vascular contraction than 1 and 2. This effect of 3 was endothelium-independent and reversible. The present results suggest that 3 is more potent than 1 and 2 and may contribute to a great extent to the ability of S. przewalskii roots to inhibit vascular contractions. |
| WOS关键词 | SALVIA-MILTIORRHIZA ; ACTIVE COMPONENTS ; CHROMATOGRAPHY ; REPERFUSION ; TANSHINONES ; ISCHEMIA |
| 资助项目 | Committee on Research and Conference Grant, University of Hong Kong[00000000] |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000261335800006 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279455]  |
| 专题 | 天然药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Leung, Susan W. S. |
| 作者单位 | 1.Univ Hong Kong, Li Ka Shing Fac Med, Dept Pharmacol, Hong Kong, Hong Kong, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wan, Alan K. S.,Leung, Susan W. S.,Zhu, Da-Yuan,et al. Vascular Effects of Different Lipophilic Components of "Danshen", a Traditional Chinese Medicine, in the Isolated Porcine Coronary Artery[J]. JOURNAL OF NATURAL PRODUCTS,2008,71(11):1825-1828. |
| APA | Wan, Alan K. S.,Leung, Susan W. S.,Zhu, Da-Yuan,&Man, Ricky Y. K..(2008).Vascular Effects of Different Lipophilic Components of "Danshen", a Traditional Chinese Medicine, in the Isolated Porcine Coronary Artery.JOURNAL OF NATURAL PRODUCTS,71(11),1825-1828. |
| MLA | Wan, Alan K. S.,et al."Vascular Effects of Different Lipophilic Components of "Danshen", a Traditional Chinese Medicine, in the Isolated Porcine Coronary Artery".JOURNAL OF NATURAL PRODUCTS 71.11(2008):1825-1828. |
入库方式： OAI收割
来源：上海药物研究所
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