Total Synthesis of a Hyperbranched N-Linked Hexasaccharide Attached to ATCV-1 Major Capsid Protein without Precedent
文献类型：期刊论文
| 作者 | Wang, Yong-Shi1; Wu, Yong1; Xiong, De-Cai1,2; Ye, Xin-Shan1 |
| 刊名 | CHINESE JOURNAL OF CHEMISTRY
 |
| 出版日期 | 2019-01 |
| 卷号 | 37期号:1页码:42-48 |
| 关键词 | N-glycan ATCV-1 one-pot glycosylation total synthesis carbohydrates |
| ISSN号 | 1001-604X |
| DOI | 10.1002/cjoc.201800533 |
| 文献子类 | Article |
| 英文摘要 | .Summary of main observation and conclusion The N-glycans attached to some chloroviruses comprise a hyperbranched core structure without precedent. We are interested in the chemical synthesis of the hexasaccharide attached to ATCV-1 (Acanthocystis turfacea Chlorella virus 1) for its distinct structure. After exploring four routes, the target hexasaccharide 2 was successfully synthesized for the first time in overall 10% yield over 8 steps from thioglycoside building blocks. This synthetic protocol is characterized by the three-component one-pot glycosylation and the regioselective glycosylation reactions. The disclosed synthetic approach to this new type of N-glycans will facilitate the in-depth understanding of their biological functions. |
| WOS关键词 | ONE-POT SYNTHESIS ; CHLOROVIRUS ATCV-1 ; CHEMICAL-SYNTHESIS ; GLYCOSYLATION ; FRAGMENTS ; GLYCANS ; ANTIGEN ; PART |
| 资助项目 | National Key R&D Program of China[2018YFA0507602] ; National Natural Science Foundation of China[21572012] ; National Natural Science Foundation of China[21772006] ; State Key Laboratory of Chem. Drug Research[SIMM1803KF-02] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000453403000007 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279460]  |
| 专题 | 新药研究国家重点实验室 中科院受体结构与功能重点实验室 |
| 通讯作者 | Ye, Xin-Shan |
| 作者单位 | 1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Xue Yuan Rd 38, Beijing 100191, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Yong-Shi,Wu, Yong,Xiong, De-Cai,et al. Total Synthesis of a Hyperbranched N-Linked Hexasaccharide Attached to ATCV-1 Major Capsid Protein without Precedent[J]. CHINESE JOURNAL OF CHEMISTRY,2019,37(1):42-48. |
| APA | Wang, Yong-Shi,Wu, Yong,Xiong, De-Cai,&Ye, Xin-Shan.(2019).Total Synthesis of a Hyperbranched N-Linked Hexasaccharide Attached to ATCV-1 Major Capsid Protein without Precedent.CHINESE JOURNAL OF CHEMISTRY,37(1),42-48. |
| MLA | Wang, Yong-Shi,et al."Total Synthesis of a Hyperbranched N-Linked Hexasaccharide Attached to ATCV-1 Major Capsid Protein without Precedent".CHINESE JOURNAL OF CHEMISTRY 37.1(2019):42-48. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。