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Apoferritin nanocages loading mertansine enable effective eradiation of cancer stem-like cells in vitro

文献类型：期刊论文

作者Tan, Tao1; Wang, Yuqi1; Wang, Hong2,3; Cao, Haiqiang2,3; Wang, Zhiwan2,3; Wang, Jing2,3; Li, Jie2,3; Li, Yaping2,3; Zhang, Zhiwen2,3; Wang, Siling1
刊名INTERNATIONAL JOURNAL OF PHARMACEUTICS
出版日期2018-12-20
卷号553期号:1-2页码:201-209
关键词Apoferritin Mertansine Cancer stem cells Breast cancer Nanocages Drug delivery
ISSN号0378-5173
DOI10.1016/j.ijpharm.2018.10.038
文献子类Article
英文摘要Cancer stem-like cells (CSCs) are proposed to be responsible for tumor metastasis, resistance and relapse after therapy, but are unable to be eliminated by many current therapies. Herein, we report that the apoferritin nanocages loading cytotoxic mertansine (M-AFN) can significantly improve their uptake in CSCs-enriched tumorspheres and effectively eradicate CSCs in tumorspheres for anticancer therapy. M-AFN were uniformly nanocage structures with the mean diameter of 11.26 +/- 2.58 nm and the loading capacity of 0.62%. In the CSCs-enriched tumorsphere model, M-AFN could be preferentially internalized by tumorsphere cells and the average half-inhibitory concentration (IC50) of M-AFN was obviously reduced by 5.46-fold when comparing to the parent 4T1 breast cancer cells. Moreover, both the already existing tumorspheres and the formation of secondary tumorspheres were drastically disrupted by M-AFN, but barely impacted by mertansine alone. The flow cytometer analysis showed the CSCs fractions in tumorspheres were considerably reduced by the M-AFN treatment. Therefore, the apoferritin nanocages represent an encouraging nanoplatform to eradicate CSCs for effective anticancer therapy.
WOS关键词FERRITIN NANOCAGES ; LUNG METASTASIS ; TUMOR ; DELIVERY ; THERAPY ; NANOPARTICLES ; NANOMEDICINES ; DOXORUBICIN ; GLIOBLASTOMA ; FORMULATION
资助项目National Basic Research Program of China[2015CB932103] ; National Natural Science Foundation of China[31771092] ; National Natural Science Foundation of China[81521005] ; National Natural Science Foundation of China[81690265] ; Youth Innovation Promotion Association of Chinese Academy of Sciences[00000000]
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000451020300019
出版者ELSEVIER SCIENCE BV
源URL[http://119.78.100.183/handle/2S10ELR8/279465]  
专题药物制剂研究中心
中科院受体结构与功能重点实验室
新药研究国家重点实验室
通讯作者Zhang, Zhiwen; Wang, Siling
作者单位1.Shenyang Pharmaceut Univ, Sch Pharm, Shenyang 110016, Liaoning, Peoples R China;
2.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China;
3.Chinese Acad Sci, Ctr Pharmaceut, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Tan, Tao,Wang, Yuqi,Wang, Hong,et al. Apoferritin nanocages loading mertansine enable effective eradiation of cancer stem-like cells in vitro[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2018,553(1-2):201-209.
APA Tan, Tao.,Wang, Yuqi.,Wang, Hong.,Cao, Haiqiang.,Wang, Zhiwan.,...&Wang, Siling.(2018).Apoferritin nanocages loading mertansine enable effective eradiation of cancer stem-like cells in vitro.INTERNATIONAL JOURNAL OF PHARMACEUTICS,553(1-2),201-209.
MLA Tan, Tao,et al."Apoferritin nanocages loading mertansine enable effective eradiation of cancer stem-like cells in vitro".INTERNATIONAL JOURNAL OF PHARMACEUTICS 553.1-2(2018):201-209.

入库方式： OAI收割

来源：上海药物研究所

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