Direct Synthesis of 3-Acylindoles through Rhodium(III)-Catalyzed Annulation of N-Phenylamidines with alpha-Cl Ketones
文献类型：期刊论文
| 作者 | Zhou, Jianhui3; Li, Jian1,2; Li, Yazhou1,2; Wu, Chenglin1,2; He, Guoxue1,2; Yang, Qiaolan1,2; Zhou, Yu1,2 ; Liu, Hong1,2
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| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2018-12-07 |
| 卷号 | 20期号:23页码:7645-7649 |
| ISSN号 | 1523-7060 |
| DOI | 10.1021/acs.orglett.8b03383 |
| 文献子类 | Article |
| 英文摘要 | In the present study, a novel synthetic strategy to directly produce versatile 3-acylindoles through Rh(III)-catalyzed C-H activation and annulation cascade of N-phenylamidines with alpha-Cl ketones was developed, in which alpha-Cl ketones serve as unusual one-carbon (sp(3)) synthons. This strategy features high regioselectivity, efficiency, wide substrate tolerance, and mild reaction conditions, which further underscore its synthetic utility in drug molecule synthesis. |
| WOS关键词 | FRIEDEL-CRAFTS ACYLATION ; INDOLE SYNTHESIS ; H ACTIVATION ; RH(III)-CATALYZED SYNTHESIS ; EFFICIENT SYNTHESIS ; DIAZO-COMPOUNDS ; ALKYNES ; ROUTE ; BOND ; FUNCTIONALIZATION |
| 资助项目 | National Natural Science Foundation of China[21672232] ; National Natural Science Foundation of China[21632008] ; National Natural Science Foundation of China[81620108027] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDA12040217] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000452930100066 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279470]  |
| 专题 | 药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 药理学第一研究室 |
| 通讯作者 | Zhou, Yu; Liu, Hong |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Receptor Res, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China; 3.Nanchang Univ, Sch Pharm, 461 Bayi Rd, Nanchang 330006, Jiangxi, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Zhou, Jianhui,Li, Jian,Li, Yazhou,et al. Direct Synthesis of 3-Acylindoles through Rhodium(III)-Catalyzed Annulation of N-Phenylamidines with alpha-Cl Ketones[J]. ORGANIC LETTERS,2018,20(23):7645-7649. |
| APA | Zhou, Jianhui.,Li, Jian.,Li, Yazhou.,Wu, Chenglin.,He, Guoxue.,...&Liu, Hong.(2018).Direct Synthesis of 3-Acylindoles through Rhodium(III)-Catalyzed Annulation of N-Phenylamidines with alpha-Cl Ketones.ORGANIC LETTERS,20(23),7645-7649. |
| MLA | Zhou, Jianhui,et al."Direct Synthesis of 3-Acylindoles through Rhodium(III)-Catalyzed Annulation of N-Phenylamidines with alpha-Cl Ketones".ORGANIC LETTERS 20.23(2018):7645-7649. |
入库方式： OAI收割
来源：上海药物研究所
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