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Deep Tumor-Penetrated Nanocages Improve Accessibility to Cancer Stem Cells for Photothermal-Chemotherapy of Breast Cancer Metastasis

文献类型：期刊论文

作者Tan, Tao1,2,3; Wang, Hong1,3; Cao, Haiqiang1,3; Zeng, Lijuan2; Wang, Yuqi1,2,3; Wang, Zhiwan1,3; Wang, Jing1,3; Li, Jie1,3; Wang, Siling2; Zhang, Zhiwen1,3
刊名ADVANCED SCIENCE
出版日期2018-12
卷号5期号:12
关键词cancer metastasis cancer stem cells deep tumor penetration drug delivery nanocages
ISSN号2198-3844
DOI10.1002/advs.201801012
文献子类Article
英文摘要Cancer stem cells (CSCs) are proposed to account for the initiation of cancer metastasis, but their accessibility remains a great challenge. This study reports deep tumor-penetrated biomimetic nanocages to augment the accessibility to CSCs fractions in tumor for anti-metastasis therapy. The nanocages can load photothermal agent of 1,1-dioctadecyl-3,3,3,3-tetramethylindotricarbocyanine iodide (DBN) and chemotherapeutic epirubicin (EBN) to eradicate CSCs for photothermal-chemotherapy of breast cancer metastasis. In metastatic 4T1-indcued tumor model, both DBN and EBN can efficiently accumulate in tumor sites and feasibly permeate throughout the tumor mass. These biomimetic nanosystems can be preferentially internalized by cancer cells and effectively accessed to CSCs fractions in tumor. The DBN+laser/EBN treatment produces considerable depression of primary tumor growth, drastically eradicates around 80% of CSCs fractions in primary tumor, and results in 95.2% inhibition of lung metastasis. Thus, the biomimetic nanocages can be a promising delivery nanovehicle with preferential CSCs-accessibility for effective anti-metastasis therapy.
WOS关键词FERRITIN NANOCAGES ; LUNG METASTASIS ; IN-VIVO ; NANOPARTICLES ; THERAPY ; TARGETS ; DOXORUBICIN ; FIBROBLASTS ; INHIBITION ; CHALLENGES
资助项目National Basic Research Program of China[2015CB932103] ; National Natural Science Foundation of China[31771092] ; National Natural Science Foundation of China[81521005] ; National Natural Science Foundation of China[81690265] ; Youth Innovation Promotion Association of Chinese Academy of Sciences[00000000]
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science
语种英语
WOS记录号WOS:000453685900012
出版者WILEY
源URL[http://119.78.100.183/handle/2S10ELR8/279472]  
专题药物制剂研究中心
中科院受体结构与功能重点实验室
新药研究国家重点实验室
通讯作者Wang, Siling; Zhang, Zhiwen; Li, Yaping
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China;
2.Shenyang Pharmaceut Univ, Sch Pharm, Shenyang 110016, Liaoning, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China;
推荐引用方式
GB/T 7714		 Tan, Tao,Wang, Hong,Cao, Haiqiang,et al. Deep Tumor-Penetrated Nanocages Improve Accessibility to Cancer Stem Cells for Photothermal-Chemotherapy of Breast Cancer Metastasis[J]. ADVANCED SCIENCE,2018,5(12).
APA Tan, Tao.,Wang, Hong.,Cao, Haiqiang.,Zeng, Lijuan.,Wang, Yuqi.,...&Li, Yaping.(2018).Deep Tumor-Penetrated Nanocages Improve Accessibility to Cancer Stem Cells for Photothermal-Chemotherapy of Breast Cancer Metastasis.ADVANCED SCIENCE,5(12).
MLA Tan, Tao,et al."Deep Tumor-Penetrated Nanocages Improve Accessibility to Cancer Stem Cells for Photothermal-Chemotherapy of Breast Cancer Metastasis".ADVANCED SCIENCE 5.12(2018).

入库方式： OAI收割

来源：上海药物研究所

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