Ainsliatriolides A and B, Two Guaianolide Trimers from Ainsliaea fragrans and Their Cytotoxic Activities
文献类型：期刊论文
| 作者 | Zhang, Rui2,3,4; Tang, Chunping2,3,6 ; Liu, Hong-Chun1; Ren, Yongmei2,3,4,5; Xu, Cheng-hui1; Ke, Chang-Qiang2,3,6; Yao, Sheng2,3,6; Huang, Xun1; Ye, Yang2,3,4,5,6
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| 刊名 | JOURNAL OF ORGANIC CHEMISTRY
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| 出版日期 | 2018-11-16 |
| 卷号 | 83期号:22页码:14175-14180 |
| ISSN号 | 0022-3263 |
| DOI | 10.1021/acs.joc.8b02346 |
| 文献子类 | Article |
| 英文摘要 | Ainsliatriolides A (1) and B (2), two guaianolide sesquiterpenoid trimers possessing an unprecedented skeleton, were isolated from Ainsliaea fragrans. Their structures were elucidated through extensive analysis of spectroscopic data and confirmed by single-crystal X-ray diffraction experiment. Ainsliatriolides A and B are first examples of compound trimerized from guaianolide sesquiterpenoids through two different C-C linkages (type A, 4-2'/15-14'; type B, 15'-15 ''). Ainsliatriolide A displayed potent cytotoxicity with an averaged IC50 value of 1.17 mu M against four cancer cells. |
| WOS关键词 | BIOMIMETIC SYNTHESES ; LACTONES |
| 资助项目 | National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program"[2015ZX09103002] ; National Natural Science Foundation of China[81573305] ; National Natural Science Foundation of China[81673327] ; International Partnership Program of Chinese Academy of Sciences[153631KYSB20160004] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000451101000056 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279492]  |
| 专题 | 药理学第一研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 天然药物化学研究室 |
| 通讯作者 | Huang, Xun; Ye, Yang |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Div Antitumor Pharmacol, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Nat Prod Chem Dept, Shanghai 201203, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 4.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China; 5.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 6.SIMM CUHK Joint Res Lab Promoting Globalizat Trad, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Zhang, Rui,Tang, Chunping,Liu, Hong-Chun,et al. Ainsliatriolides A and B, Two Guaianolide Trimers from Ainsliaea fragrans and Their Cytotoxic Activities[J]. JOURNAL OF ORGANIC CHEMISTRY,2018,83(22):14175-14180. |
| APA | Zhang, Rui.,Tang, Chunping.,Liu, Hong-Chun.,Ren, Yongmei.,Xu, Cheng-hui.,...&Ye, Yang.(2018).Ainsliatriolides A and B, Two Guaianolide Trimers from Ainsliaea fragrans and Their Cytotoxic Activities.JOURNAL OF ORGANIC CHEMISTRY,83(22),14175-14180. |
| MLA | Zhang, Rui,et al."Ainsliatriolides A and B, Two Guaianolide Trimers from Ainsliaea fragrans and Their Cytotoxic Activities".JOURNAL OF ORGANIC CHEMISTRY 83.22(2018):14175-14180. |
入库方式： OAI收割
来源：上海药物研究所
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