Inverse-Electron-Demand Diels-Alder Reactions for the Synthesis of Pyridazines on DNA
文献类型：期刊论文
| 作者 | Li, Hailong3; Sun, Zhen3; Wu, Wenting3; Wang, Xuan1,3; Zhang, Mingqiang3; Lu, Xiaojie1 ; Zhong, Wenge2,3; Dai, Dongcheng3
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| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2018-11-16 |
| 卷号 | 20期号:22页码:7186-7191 |
| ISSN号 | 1523-7060 |
| DOI | 10.1021/acs.orglett.8b03114 |
| 文献子类 | Article |
| 英文摘要 | The synthesis of pyridazines on DNA has been developed on the basis of inverse-electron-demand Diels-Alder (IEDDA) reactions of 1,2,4,5-tetrazines. The broad substrate scope is explored. Functionalized pyridazine products are selected for subsequent DNA-compatible Suzuki Miyaura coupling, acylation, and SNAr substitution reactions, demonstrating the feasibility and versatility of IEDDA reactions for DNA-encoded library synthesis. |
| WOS关键词 | ENCODED CHEMICAL LIBRARIES ; HETEROCYCLIC AZADIENES ; TECHNOLOGY ; DISCOVERY ; NINGALIN |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000451101500046 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279493]  |
| 专题 | 药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Dai, Dongcheng |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 501 Haike Rd,Zhang Jiang Hitech Pk, Shanghai 200031, Peoples R China; 2.Regor Therapeut Inc, Shanghai, Peoples R China 3.Amgen Res, Amgen Asia R&D Ctr, Dept Discovery Modal, 4560 Jinke Rd, Shanghai 201210, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Li, Hailong,Sun, Zhen,Wu, Wenting,et al. Inverse-Electron-Demand Diels-Alder Reactions for the Synthesis of Pyridazines on DNA[J]. ORGANIC LETTERS,2018,20(22):7186-7191. |
| APA | Li, Hailong.,Sun, Zhen.,Wu, Wenting.,Wang, Xuan.,Zhang, Mingqiang.,...&Dai, Dongcheng.(2018).Inverse-Electron-Demand Diels-Alder Reactions for the Synthesis of Pyridazines on DNA.ORGANIC LETTERS,20(22),7186-7191. |
| MLA | Li, Hailong,et al."Inverse-Electron-Demand Diels-Alder Reactions for the Synthesis of Pyridazines on DNA".ORGANIC LETTERS 20.22(2018):7186-7191. |
入库方式： OAI收割
来源：上海药物研究所
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