Isocryptolepine, an indoloquinoline alkaloid from Cryptolepis sanguinolenta promotes LDL uptake in HepG2 cells
文献类型：期刊论文
| 作者 | Aggrey, Mike Okweesi1,2; Li, Hui-Hui1,2; Wang, Wen-Qiong2; Song, Weibin2; Wang, Yiping2 ; Xuan, Li-Jiang2
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| 刊名 | REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY
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| 出版日期 | 2018-11 |
| 卷号 | 28期号:6页码:654-657 |
| 关键词 | Antihyperlipidemia Atherosclerosis Dil-LDL uptake HepG2 cells lsocryptolepine SAR |
| ISSN号 | 0102-695X |
| DOI | 10.1016/j.bjp.2018.08.008 |
| 文献子类 | Article |
| 英文摘要 | About 31 percent of deaths worldwide result from atherosclerotic cardiovascular disease. Hyperlipidemia remains the major risk factor for this disease and therefore, it is necessary to identify antihyperlipidemic compounds for drug development. The crude ethanolic extract of Cryptolepis sanguinolenta (Lindl.) Schltr., Apocynaceae, has demonstrated antihyperlipidemic properties. However, the chemical constituents responsible for this action are unknown. Hence, to identify chemical constituent(s) of C. sanguinolenta with anti-hyperlipidemic effect, five indoloquinoline alkaloids were isolated and evaluated in 1,1'-dioctadecyl-3,3,3',3'-tetramethyl-indocarbocyanine perchlorate labeled low density lipoprotein uptake assay using HepG2 cells. The minor alkaloid, isocryptolepine, showed strong activity in promoting low lipid lipoprotein uptake by 1.85-fold. Isocryptolepine may, therefore, serve as a lead compound for future studies in the development of novel antihyperlipidemic drugs. (C) 2018 Published by Elsevier Editora Ltda. on behalf of Sociedade Brasileira de Farmacognosia. |
| WOS关键词 | QUINDOLINE ; MANAGEMENT ; DISCOVERY |
| 资助项目 | CAS-TWAS President's Fellowship for International Doctoral Students[00000000] ; State Key Laboratory of Drug Research[SIMM1601ZZ-03] ; National Science Foundation of China[81773863] ; National Science Foundation of China[21702219] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000448206500004 |
| 出版者 | SOC BRASILEIRA FARMACOGNOSIA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279517]  |
| 专题 | 上海中药现代化研究中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Xuan, Li-Jiang |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Aggrey, Mike Okweesi,Li, Hui-Hui,Wang, Wen-Qiong,et al. Isocryptolepine, an indoloquinoline alkaloid from Cryptolepis sanguinolenta promotes LDL uptake in HepG2 cells[J]. REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY,2018,28(6):654-657. |
| APA | Aggrey, Mike Okweesi,Li, Hui-Hui,Wang, Wen-Qiong,Song, Weibin,Wang, Yiping,&Xuan, Li-Jiang.(2018).Isocryptolepine, an indoloquinoline alkaloid from Cryptolepis sanguinolenta promotes LDL uptake in HepG2 cells.REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY,28(6),654-657. |
| MLA | Aggrey, Mike Okweesi,et al."Isocryptolepine, an indoloquinoline alkaloid from Cryptolepis sanguinolenta promotes LDL uptake in HepG2 cells".REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY 28.6(2018):654-657. |
入库方式： OAI收割
来源：上海药物研究所
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