中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 上海药物研究所
  3. 中国科学院上海药物研究所
  4. 药物制剂研究中心
Antiglioma via regulating oxidative stress and remodeling tumor-associated macrophage using lactoferrin-mediated biomimetic codelivery of simvastatin/fenretinide

文献类型：期刊论文

作者Mo, Xiaopeng2,3; Zheng, Zening1,3; He, Yang3; Zhone, Huihai2,3; Kane, Xuejia1,3; Shi, Mingjie3; Liu, Tuanbing3; Jiao, Zheng2; Huang, Yongzhuo3
刊名JOURNAL OF CONTROLLED RELEASE
出版日期2018-10-10
卷号287页码:12-23
关键词Lactoferrin nanoparticle Reactive oxygen species Tumor-associated macrophages Brain-targeted delivery Biomimetic delivery Cell penetrating peptide Fenretinide Simvastatin
ISSN号0168-3659
DOI10.1016/j.jconrel.2018.08.012
文献子类Article
英文摘要Effective treatment of malignant glioma still remains a formidable challenge due to lack of the effective BBB-permeable drugs and efficient brain delivery methods, and the pharmacotherapy options are very limited. Therefore, to develop an effective therapeutic strategy is a pressing need. In this work, a noncytotoxic drug combination (i.e., simvastatin and fenretinide) was revealed to be potent for treating glioma, which was co-encapsulated into a TPGS-TAT-embedded lactoferrin nanoparticle system for achieving brain-targeted biomimetic delivery via the LRP-1 receptor. It was shown that the lactoferrin nanoparticle repolarized the tumor-associated macrophages from the M2 phenotype to M1 via regulating the STAT6 pathway, as well as induced the ROS-mediated mitochondrial apoptosis by inhibiting the Ras/Raf/p-Erk pathway in the glioma cells. The antiglioma efficacy was further demonstrated in both the subcutaneous and orthotopic glioma models. The repolarization of tumor-associated macrophages not only prompted the ROS generation but also induced the innate immunity (e.g., anti-tumor cytokine release). This delivery and therapeutic strategy provides a novel modality for the glioma treatment.
WOS关键词RANDOMIZED PHASE-III ; JNK ACTIVATION ; CANCER-CELLS ; DELIVERY ; GLIOMA ; FENRETINIDE ; APOPTOSIS ; ROS ; MICROENVIRONMENT ; EPIDEMIOLOGY
资助项目973 Program, China[2014CB931900] ; NFSC[814022883] ; NFSC[81422048] ; NFSC[81673382] ; NFSC[81521005] ; Strategic Priority Research Program of CAS[XDA12050307] ; National Special Project for Significant New Drugs Development[2018ZX09711002-010-002] ; CAS Scientific Research and Equipment Development Project[YZ201437] ; Fudan-SIMM Joint Research Fund[FU-SIMM20174009]
WOS研究方向Chemistry ; Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000445127000002
出版者ELSEVIER SCIENCE BV
源URL[http://119.78.100.183/handle/2S10ELR8/279535]  
专题药物制剂研究中心
中科院受体结构与功能重点实验室
新药研究国家重点实验室
通讯作者Huang, Yongzhuo
作者单位1.Guangzhou Univ Chinese Med, Inst Trop Med, Guangzhou 510405, Guangdong, Peoples R China
2.Shanghai Univ, Coll Sci, Shanghai 200444, Peoples R China;
3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 501 Haike Rd, Shanghai 201203, Peoples R China;
推荐引用方式
GB/T 7714		 Mo, Xiaopeng,Zheng, Zening,He, Yang,et al. Antiglioma via regulating oxidative stress and remodeling tumor-associated macrophage using lactoferrin-mediated biomimetic codelivery of simvastatin/fenretinide[J]. JOURNAL OF CONTROLLED RELEASE,2018,287:12-23.
APA Mo, Xiaopeng.,Zheng, Zening.,He, Yang.,Zhone, Huihai.,Kane, Xuejia.,...&Huang, Yongzhuo.(2018).Antiglioma via regulating oxidative stress and remodeling tumor-associated macrophage using lactoferrin-mediated biomimetic codelivery of simvastatin/fenretinide.JOURNAL OF CONTROLLED RELEASE,287,12-23.
MLA Mo, Xiaopeng,et al."Antiglioma via regulating oxidative stress and remodeling tumor-associated macrophage using lactoferrin-mediated biomimetic codelivery of simvastatin/fenretinide".JOURNAL OF CONTROLLED RELEASE 287(2018):12-23.

入库方式： OAI收割

来源：上海药物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。