Total synthesis of lithospermic acid using Fe-catalyzed Cross-Dehydrogenative-Coupling reaction and Pd-catalyzed ester-directed C-H olefination
文献类型：期刊论文
| 作者 | Zheng, Yong; Song, Weibin; Zhu, Yefu; Wei, Bole; Xuan, Lijiang
|
| 刊名 | TETRAHEDRON
 |
| 出版日期 | 2018-10-04 |
| 卷号 | 74期号:40页码:5950-5954 |
| ISSN号 | 0040-4020 |
| 关键词 | Total synthesis Lithospermic acid Cross-Dehydrogenative-Coupling C-H olefination |
| DOI | 10.1016/j.tet.2018.08.028 |
| 文献子类 | Article |
| 英文摘要 | The total synthesis of lithospermic acid has been accomplished employing two C-H activation reactions as key steps. Fe-catalyzed Cross-Dehydrogenative-Coupling reaction was used for the rapid construction of benzofuran framework. Pd-catalyzed ester-directed C-H olefination allowed the efficient assembly of the dihydrobenzofuran ester and acrylate moieties. (C) 2018 Elsevier Ltd. All rights reserved. |
| WOS关键词 | ENANTIOSELECTIVE TOTAL-SYNTHESIS ; (+)-LITHOSPERMIC ACID ; SALVIA-MILTIORRHIZA ; BOND ACTIVATION ; PHENOLS ; BENZOFURANS ; CHEMISTRY ; OXIDATION ; RUDERALE ; DANSHEN |
| 资助项目 | National Natural Science Foundation of China[81602995] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| WOS记录号 | WOS:000446950200018 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279541]  |
| 专题 | 上海中药现代化研究中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Xuan, Lijiang |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 501 Haike Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zheng, Yong,Song, Weibin,Zhu, Yefu,et al. Total synthesis of lithospermic acid using Fe-catalyzed Cross-Dehydrogenative-Coupling reaction and Pd-catalyzed ester-directed C-H olefination[J]. TETRAHEDRON,2018,74(40):5950-5954. |
| APA | Zheng, Yong,Song, Weibin,Zhu, Yefu,Wei, Bole,&Xuan, Lijiang.(2018).Total synthesis of lithospermic acid using Fe-catalyzed Cross-Dehydrogenative-Coupling reaction and Pd-catalyzed ester-directed C-H olefination.TETRAHEDRON,74(40),5950-5954. |
| MLA | Zheng, Yong,et al."Total synthesis of lithospermic acid using Fe-catalyzed Cross-Dehydrogenative-Coupling reaction and Pd-catalyzed ester-directed C-H olefination".TETRAHEDRON 74.40(2018):5950-5954. |
入库方式： OAI收割
来源：上海药物研究所
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