Rational Design of Nanoparticles with Deep Tumor Penetration for Effective Treatment of Tumor Metastasis
文献类型：期刊论文
| 作者 | Zhang, Zhiwen1,3 ; Wang, Hong1,3; Tan, Tao1,3; Li, Jie1,3; Wang, Zhiwan1,3; Li, Yaping1,2,3
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| 刊名 | ADVANCED FUNCTIONAL MATERIALS
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| 出版日期 | 2018-10-04 |
| 卷号 | 28期号:40 |
| 关键词 | drug delivery metastasis nanoparticles penetration tumors |
| ISSN号 | 1616-301X |
| DOI | 10.1002/adfm.201801840 |
| 文献子类 | Review |
| 英文摘要 | The limited penetration of nanoparticles in primary tumors and metastases remains a great challenge for effective treatment of tumor metastasis. This review outlines the current approaches and summarizes the rational design of nanoparticles with deep tumor penetration capacity for anti-metastasis treatment. There are two ways to achieve better tumor penetration; through rational regulation of the physicochemical properties of nanoparticles and through remodeling of the tumor microenvironment, including the tumor vasculature and stromal environment. Moreover, biomimetic strategies that integrate the advantages of nanoparticles and metastasis-homing molecules during cancer cell metastasis are discussed. These efforts have led to promising results in facilitating intratumoral permeation of various nanoparticles to enhance antitumor effects. The considerations and some feasible future directions for deep tumor penetration strategies are proposed to improve tumor metastasis therapies. |
| WOS关键词 | MESENCHYMAL STEM-CELLS ; TARGETED DRUG-DELIVERY ; GUIDED PHOTOTHERMAL THERAPY ; COMBINATION CANCER-THERAPY ; LUNG MELANOMA METASTASES ; BREAST-CANCER ; IN-VIVO ; SOLID TUMORS ; POLYMERIC MICELLES ; EXTRACELLULAR-MATRIX |
| 资助项目 | National Basic Research Program of China[2015CB932103] ; National Natural Science Foundation of China[31771092] ; National Natural Science Foundation of China[81521005] ; National Natural Science Foundation of China[81690265] ; Youth Innovation Promotion Association of CAS[00000000] |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:000446155700004 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279542]  |
| 专题 | 药物制剂研究中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Zhang, Zhiwen; Li, Yaping |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 2.Yantai Univ, Sch Pharm, Yantai 264005, Shandong, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Zhang, Zhiwen,Wang, Hong,Tan, Tao,et al. Rational Design of Nanoparticles with Deep Tumor Penetration for Effective Treatment of Tumor Metastasis[J]. ADVANCED FUNCTIONAL MATERIALS,2018,28(40). |
| APA | Zhang, Zhiwen,Wang, Hong,Tan, Tao,Li, Jie,Wang, Zhiwan,&Li, Yaping.(2018).Rational Design of Nanoparticles with Deep Tumor Penetration for Effective Treatment of Tumor Metastasis.ADVANCED FUNCTIONAL MATERIALS,28(40). |
| MLA | Zhang, Zhiwen,et al."Rational Design of Nanoparticles with Deep Tumor Penetration for Effective Treatment of Tumor Metastasis".ADVANCED FUNCTIONAL MATERIALS 28.40(2018). |
入库方式： OAI收割
来源：上海药物研究所
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