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Cembrane-type diterpenoids from the South China Sea soft coral Sarcophyton mililatensis

文献类型：期刊论文

作者Li, Songwei2,3; Ye, Fei3; Zhu, Zhengdan3; Huang, Hui1; Mao, Shuichun2; Guo, Yuewei3
刊名ACTA PHARMACEUTICA SINICA B
出版日期2018-10
卷号8期号:6页码:944-955
ISSN号2211-3835
关键词Soft coral Sureophyton Sarcophyton mililatensis Cembrane-type diterpenoids Modified Mosher's method ECD calculation Cytotoxieity NE-kappa B inhibitory activity
DOI10.1016/j.apsb.2018.06.004
文献子类Article
英文摘要Eight cembrane-type diterpenoids, namely, (+)-(6R)-6-hydroxyisosarcophytoxide (1), (+)-(6R)-6-acetoxyisosarcophytoxide (2), (+)-17-hydroxyisosarcophytoxide (3), sarcomililatins A-D (4-7), and sarcomililatol (8), were isolated from the soft coral Sarcophyton mililatensis collected from Weizhou Island, Guangxi Autonomous Region, together with 2 known related analogues, (+)-isosarco phytoxide (9) and (+)-isosarcophine (10). The structures of these compounds were elucidated by a combination of detailed spectroscopic analyses, chemical methods, and comparison with reported data. The absolute configuration of compound 1 was established by the modified Mosher's method, while the absolute configurations of compounds 4 and 5 were assigned by electronic circular dichroism (ECD) spectroscopy and that of compound 8 was established by time-dependent density functional theory electronic circular dichroism (TD-DFT ECD) calculation. In in vitro bioassays, compound 9 displayed significant cytotoxicity against the human cancer cell lines human promyelocytic leukemia cells (HL-60) and human lung adenocarcinoma cells (A-549) with IC50 values of 0.78 +/- 0.21 and 1.26+0.80 +/- 1.26+0.80 mu mol/L, respectively. Compounds 4 and 9 also showed moderate inhibitory effects on the TNF alpha-induced Nuclear factor kappa B (NF-kappa B, a therapeutical target in cancer) activation, showing IC50 values of 35.23 +/- 12.42 and 22.52 +/- 4.44 mu mol/L, respectively. (C) 2018 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.
WOS关键词FACTOR-KAPPA-B ; ABSOLUTE-CONFIGURATION ; TARGET ; DERIVATIVES
资助项目Natural Science Foundation of China[41506187] ; Natural Science Foundation of China[81520108028] ; Natural Science Foundation of China[21672230] ; Natural Science Foundation of China[81603022] ; NSFC-Shandong Joint Fund for Marine Science Research Centers[U1606403] ; SCTSM Project[15431901000] ; SKLDR/SIMM Projects[SIMM 1705ZZ-01]
WOS研究方向Pharmacology & Pharmacy
语种英语
出版者INST MATERIA MEDICA, CHINESE ACAD MEDICAL SCIENCES
WOS记录号WOS:000451117700010
源URL[http://119.78.100.183/handle/2S10ELR8/279546]  
专题天然药物化学研究室
中科院受体结构与功能重点实验室
新药研究国家重点实验室
通讯作者Mao, Shuichun; Guo, Yuewei
作者单位1.Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Marine Bioresources Sustainable Utilizat, Guangzhou 510301, Guangdong, Peoples R China
2.Nanchang Univ, Sch Pharm, Nanchang 330006, Jiangxi, Peoples R China;
3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China;
推荐引用方式
GB/T 7714		 Li, Songwei,Ye, Fei,Zhu, Zhengdan,et al. Cembrane-type diterpenoids from the South China Sea soft coral Sarcophyton mililatensis[J]. ACTA PHARMACEUTICA SINICA B,2018,8(6):944-955.
APA Li, Songwei,Ye, Fei,Zhu, Zhengdan,Huang, Hui,Mao, Shuichun,&Guo, Yuewei.(2018).Cembrane-type diterpenoids from the South China Sea soft coral Sarcophyton mililatensis.ACTA PHARMACEUTICA SINICA B,8(6),944-955.
MLA Li, Songwei,et al."Cembrane-type diterpenoids from the South China Sea soft coral Sarcophyton mililatensis".ACTA PHARMACEUTICA SINICA B 8.6(2018):944-955.

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来源：上海药物研究所

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