Flavans and diphenylpropanes with PTP1B inhibition from Broussonetia kazinoki
文献类型：期刊论文
| 作者 | Xue, Jing-Jing2; Lei, Chun2; Wang, Pei-Pei1 ; Kim, Kwang-Yong3; Li, Jing-Ya1; Li, Jia1; Hou, Ai-Jun2
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| 刊名 | FITOTERAPIA
 |
| 出版日期 | 2018-10 |
| 卷号 | 130页码:37-42 |
| 关键词 | Moraceae Broussonetia kazinoki Flavans 1,3-Diphenylpropanes Protein tyrosine phosphatase 1B |
| ISSN号 | 0367-326X |
| DOI | 10.1016/j.fitote.2018.08.001 |
| 文献子类 | Article |
| 英文摘要 | Three new (1a/1b and 2b) and five known flavans (2a, 6a/6b, 7, and 8), one new flavan glycoside (3), and two new (4 and 5) and six known 1,3-diphenylpropanes (9-14) were isolated from the twigs of Broussonetia kazinoki. Compounds 1, 2, and 6 are scalemic mixtures, and were resolved by chiral HPLC to provide 1a/1b, 2a/2b, and 6a/6b. The structures of these compounds were elucidated by extensive spectroscopic methods, including NMR, MS, and ECD analyses. Compounds 1, 2, 5, 8, 9, 11, and 12 showed in vitro inhibition of protein tyros ine phosphatase 1B (PTP1B). |
| WOS关键词 | ISOPRENYLATED PHENOLIC-COMPOUNDS ; TYROSINE-PHOSPHATASE 1B ; PAPER MULBERRY ; CONSTITUENTS ; DERIVATIVES ; PROTEIN ; FLAVONOIDS ; SIEB |
| 资助项目 | National Natural Science Foundation of China[21372049] ; National Natural Science Foundation of China[81222045] ; Key National Scientific and Technological Program "Major New Drug Development" of China[2018ZX09735001-002-006] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000449129500006 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279549]  |
| 专题 | 药理学第三研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 药物安全性评价中心 国家新药筛选中心 |
| 通讯作者 | Hou, Ai-Jun |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Natl Ctr Drug Screening, Shanghai 201203, Peoples R China; 2.Fudan Univ, Sch Pharm, Dept Pharmacognosy, Shanghai 201203, Peoples R China; 3.Han Dock Su Pyongyang Univ Light Ind, Inst Analyt Chem, Pyongyang 999093, North Korea |
| 推荐引用方式 GB/T 7714 | Xue, Jing-Jing,Lei, Chun,Wang, Pei-Pei,et al. Flavans and diphenylpropanes with PTP1B inhibition from Broussonetia kazinoki[J]. FITOTERAPIA,2018,130:37-42. |
| APA | Xue, Jing-Jing.,Lei, Chun.,Wang, Pei-Pei.,Kim, Kwang-Yong.,Li, Jing-Ya.,...&Hou, Ai-Jun.(2018).Flavans and diphenylpropanes with PTP1B inhibition from Broussonetia kazinoki.FITOTERAPIA,130,37-42. |
| MLA | Xue, Jing-Jing,et al."Flavans and diphenylpropanes with PTP1B inhibition from Broussonetia kazinoki".FITOTERAPIA 130(2018):37-42. |
入库方式： OAI收割
来源：上海药物研究所
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