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Dictyoptesterols A-C, Delta(22)-24-oxo cholestane-type sterols with potent PTP1B inhibitory activity from the brown alga Dictyopteris undulata Holmes

文献类型：期刊论文

作者Yang, Fei1; Zhang, Liang-Wei1; Feng, Mei-Tang1; Liu, Ai-Hong2; Li, Jia3; Zhao, Tian-Sheng1; Lai, Xiao-Ping1; Wang, Bin1; Guo, Yue-Wei3; Mao, Shui-Chun1
刊名FITOTERAPIA
出版日期2018-10
卷号130页码:241-246
关键词Dictyotaceae Dictyopteris undulate Cholestane-type sterols Dictyoptesterols A-C Protein tyrosine phosphatase-1B inhibitors
ISSN号0367-326X
DOI10.1016/j.fitote.2018.09.001
文献子类Article
英文摘要Three new cholestane-type sterols bearing an unusual Delta(22)-24-oxo side chain, namely, dictyoptesterols A-C (1-3), were isolated from the brown alga Dictyopteris undulata Holmes, together with five known strutural analogues (4-8). Their structures were elucidated on the basis of by extensive spectroscopic analysis. The absolute configurations of the steroidal nuclei of the new compounds were proposed by a comparison of NMR data with those of related known compounds as well as biogenetic considerations. All of the isolates were evaluated in vitro for their potential to inhibit protein tyrosine phosphatase-1B (PTP1B) activity. The results showed that compounds 1-5 exhibited different levels of PTP1B inhibitory activities with IC50 values ranging from 3.03 +/- 0.76 to 15.01 +/- 2.88 mu M. In particular, compounds 3 and 4 showed promising inhibitory effects towards PTP1B with IC50 values of 3.03 +/- 0.76 and 3.72 +/- 0.40 mu M, respectively, when compared to the positive control oleanolic acid (IC50, 2.83 +/- 0.39 mu M). The chemotaxonomic significance of these isolated Delta(22)-24-oxo cholestanes has also been discussed.
WOS关键词CAULERPA-RACEMOSA ; 1B ; SESQUITERPENE
资助项目National Natural Science Foundation of China[81860616] ; National Natural Science Foundation of China[21362024] ; National Natural Science Foundation of China[21162016] ; Natural Science Foundation of Jiangxi Province, China[20181BAB205086] ; Natural Science Foundation of Jiangxi Province, China[20161BAB205211] ; Natural Science Foundation of Jiangxi Province, China[20151BAB205082] ; State Key Laboratory of Drug Research-SIMM[SIMM1803KF-01]
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000449129500038
出版者ELSEVIER SCIENCE BV
源URL[http://119.78.100.183/handle/2S10ELR8/279551]  
专题国家新药筛选中心
中科院受体结构与功能重点实验室
新药研究国家重点实验室
天然药物化学研究室
药物安全性评价中心
通讯作者Mao, Shui-Chun
作者单位1.Nanchang Univ, Sch Pharm, 461 Bayi Rd, Nanchang 330006, Jiangxi, Peoples R China;
2.Nanchang Univ, Ctr Anal & Testing, Nanchang 330047, Jiangxi, Peoples R China;
3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Yang, Fei,Zhang, Liang-Wei,Feng, Mei-Tang,et al. Dictyoptesterols A-C, Delta(22)-24-oxo cholestane-type sterols with potent PTP1B inhibitory activity from the brown alga Dictyopteris undulata Holmes[J]. FITOTERAPIA,2018,130:241-246.
APA Yang, Fei.,Zhang, Liang-Wei.,Feng, Mei-Tang.,Liu, Ai-Hong.,Li, Jia.,...&Mao, Shui-Chun.(2018).Dictyoptesterols A-C, Delta(22)-24-oxo cholestane-type sterols with potent PTP1B inhibitory activity from the brown alga Dictyopteris undulata Holmes.FITOTERAPIA,130,241-246.
MLA Yang, Fei,et al."Dictyoptesterols A-C, Delta(22)-24-oxo cholestane-type sterols with potent PTP1B inhibitory activity from the brown alga Dictyopteris undulata Holmes".FITOTERAPIA 130(2018):241-246.

入库方式： OAI收割

来源：上海药物研究所

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