Oncogene-induced senescence: a double edged sword in cancer
文献类型：期刊论文
| 作者 | Liu, Xue-ling; Ding, Jian ; Meng, Ling-hua
|
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 2018-10 |
| 卷号 | 39期号:10页码:1553-1558 |
| 关键词 | cellular senescence oncogene SASP tumor microenvironment cancer therapy |
| ISSN号 | 1671-4083 |
| DOI | 10.1038/aps.2017.198 |
| 文献子类 | Review |
| 英文摘要 | Oncogene-induced cellular senescence (OIS) is a complex program that is triggered in response to aberrant activation of oncogenic signaling. Initially, OIS was thought to be a barrier to malignant transformation because of its suppression on cell proliferation. Later studies showed that senescence induced by oncogenes can also promote the initiation and development of cancer. The opposing effects of OIS occur through different combinations of downstream effectors as well as the interplay of senescent cells and the microenvironment, such as senescence-associated inflammation. Here, we review the common features and molecular mechanisms underlying OIS and the interaction between senescent cells and the microenvironment. We propose that targeting senescent cells may have a beneficial therapeutic effect during the treatment of cancer. |
| WOS关键词 | RAS-INDUCED SENESCENCE ; DNA-DAMAGE RESPONSE ; CELLULAR SENESCENCE ; SECRETORY PHENOTYPE ; TUMOR-SUPPRESSOR ; STROMAL FIBROBLASTS ; GROWTH-FACTOR ; CELLS ; SURVEILLANCE ; PROGRESSION |
| 资助项目 | National Natural Science Foundation of China[81773760] |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000448391500001 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279554]  |
| 专题 | 药理学第一研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Ding, Jian; Meng, Ling-hua |
| 作者单位 | Chinese Acad Sci, Div Antitumor Pharmacol, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Xue-ling,Ding, Jian,Meng, Ling-hua. Oncogene-induced senescence: a double edged sword in cancer[J]. ACTA PHARMACOLOGICA SINICA,2018,39(10):1553-1558. |
| APA | Liu, Xue-ling,Ding, Jian,&Meng, Ling-hua.(2018).Oncogene-induced senescence: a double edged sword in cancer.ACTA PHARMACOLOGICA SINICA,39(10),1553-1558. |
| MLA | Liu, Xue-ling,et al."Oncogene-induced senescence: a double edged sword in cancer".ACTA PHARMACOLOGICA SINICA 39.10(2018):1553-1558. |
入库方式： OAI收割
来源：上海药物研究所
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