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Fluorescent Imaging of beta-Amyloid Using BODIPY Based Near-Infrared Off-On Fluorescent Probe

文献类型：期刊论文

作者Ren, Wenming4; Zhang, Jingjing3,5; Peng, Cheng1,3,5; Xiang, Huaijiang2; Chen, Jingjing3; Peng, Chengyuan4; Zhu, Weiliang1,3,5; Huang, Ruimin3,4; Zhang, Haiyan3,4,5; Hu, Youhong3,4
刊名BIOCONJUGATE CHEMISTRY
出版日期2018-10
卷号29期号:10页码:3459-3466
ISSN号1043-1802
DOI10.1021/acs.bioconjchem.8b00623
文献子类Article
英文摘要Fluorescent imaging of beta-amyloid (A beta) is one of the most promising methods for Alzheimer's disease diagnosis. Several fluorescent probes have been reported to detect A beta in vitro both in vitro and in vivo. However, highly sensitive and highly selective probes with low background signals are still greatly needed. Herein, we rationally designed and synthesized a PIET quenched near-infrared probe QAD-1 to detect A beta. This probe contains BODIPY as fluorophore and tetrahydroquinoxaline as the quenching group. QAD-1 exhibited significant fluorescent switch-on after binding to soluble and insoluble A beta species, and the probe had the benefit of low background signal to stain A beta plaques without the need of wash-out procedures in vitro, which was specially found by the fluorescence off-on probe. QAD-1 could identify the overproduced A beta in transgenic (APP(SWE)/PSEN ldE9) AD mice as early as 6 months old in vivo, which indicated that QAD-1 may be a potential probe for monitoring A beta species at an early stage of AD.
WOS关键词IN-VIVO DETECTION ; ALZHEIMERS-DISEASE ; MOUSE-BRAIN ; PLAQUES ; DESIGN ; MECHANISM ; OLIGOMERS ; DEPOSITS ; PET
资助项目National Natural Science Foundation of China[81522045] ; National Natural Science Foundation of China[81771890] ; China Postdoctoral Science Foundation[2017M611638] ; "Personalized Medicines-Molecular Signature-based Drug Discovery and Development", Strategic Priority Research Program of the Chinese Academy of Sciences[XDA12040207] ; Institutes for Drug Discovery and Development, Chinese Academy of Sciences[CASIMM0120163010] ; One Hundred Talent Program of Chinese Academy of Sciences[00000000] ; Special Program for Applied Research on Super Computation of the NSFC-Guangdong Joint Fund[U1501501]
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
语种英语
WOS记录号WOS:000447953500023
出版者AMER CHEMICAL SOC
源URL[http://119.78.100.183/handle/2S10ELR8/279557]  
专题分子影像中心（筹）
中科院受体结构与功能重点实验室
新药研究国家重点实验室
药理学第二研究室
药物化学研究室
通讯作者Huang, Ruimin; Zhang, Haiyan; Hu, Youhong
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, Drug Discovery & Design Ctr, Shanghai 201203, Peoples R China;
2.Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou 310058, Zhejiang, Peoples R China;
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Chinese Acad Sci, State Key Lab Drug Res, Shanghai 201203, Peoples R China;
5.Chinese Acad Sci, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China;
推荐引用方式
GB/T 7714		 Ren, Wenming,Zhang, Jingjing,Peng, Cheng,et al. Fluorescent Imaging of beta-Amyloid Using BODIPY Based Near-Infrared Off-On Fluorescent Probe[J]. BIOCONJUGATE CHEMISTRY,2018,29(10):3459-3466.
APA Ren, Wenming.,Zhang, Jingjing.,Peng, Cheng.,Xiang, Huaijiang.,Chen, Jingjing.,...&Hu, Youhong.(2018).Fluorescent Imaging of beta-Amyloid Using BODIPY Based Near-Infrared Off-On Fluorescent Probe.BIOCONJUGATE CHEMISTRY,29(10),3459-3466.
MLA Ren, Wenming,et al."Fluorescent Imaging of beta-Amyloid Using BODIPY Based Near-Infrared Off-On Fluorescent Probe".BIOCONJUGATE CHEMISTRY 29.10(2018):3459-3466.

入库方式： OAI收割

来源：上海药物研究所

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