Identification of novel ondansetron metabolites using LC/MSn and NMR
文献类型：期刊论文
| 作者 | Duan, Mingyu2,3; Qin, Li3; Zhong, Dafang1 ; Zhang, Peng3
|
| 刊名 | JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
 |
| 出版日期 | 2018-09-15 |
| 卷号 | 1095页码:138-141 |
| 关键词 | Ondansetron Metabolite Metabolism LC/MSn NMR |
| ISSN号 | 1570-0232 |
| DOI | 10.1016/j.jchromb.2018.07.013 |
| 文献子类 | Article |
| 英文摘要 | Ondansetron, a potent and highly sensitive 5-hydroxytryptamine type 3 (5-HT3) receptor antagonist, has been used for the treatment of chemotherapy- and radiotherapy-induced nausea and vomiting. The isolation and identification of ondansetron metabolites were investigated in our research. The feces and bile samples collected after oral administration of ondansetron were extracted and then isolated by semi-preparative HPLC. Then the pretreated samples were characterized by LC/MSn and NMR. In rats feces, a total of four metabolites were isolated and elucidated including 7-hydroxyl-ondansetron (M1), 8-hydroxyl-ondansetron (M2), 7-hydroxyl-N-desmethyl-ondansetron (M3), and 8-hydroxyl-N-desmethyl-ondansetron (M4). In addition, a kind of metabolite of phase II isolated in rats bile was characterized as N-desmethyl-ondansetron-7-O-beta-D-glucuronide (M5). To our knowledge, three metabolites were reported for the first time. LC/MSn and NMR-based approach was proved to be useful for full structure elucidation of unknown metabolites. The systematic metabolites isolation and elucidation provided metabolite reference standards for metabolites detection of ondansetron. |
| WOS关键词 | CHEMOTHERAPY-INDUCED NAUSEA ; PATIENT PERCEPTIONS ; PHARMACOKINETICS ; ANTAGONISTS ; CANCER |
| 资助项目 | '863' Program of China[2003 AA2Z347C] ; National Natural Science Foundation of China[81521005] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000444666700017 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279578]  |
| 专题 | 上海药物代谢研究中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Zhang, Peng |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 501 Haike Rd, Shanghai 201203, Peoples R China; 2.Quarkman Pharmaceut Technol Co LTD, Bioanal Ctr, A1 Innovat Pk, Benxi 117020, Liaoning, Peoples R China 3.Shenyang Pharmaceut Univ, Sch Pharm, 103 Wenhua Rd, Shenyang 110016, Liaoning, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Duan, Mingyu,Qin, Li,Zhong, Dafang,et al. Identification of novel ondansetron metabolites using LC/MSn and NMR[J]. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,2018,1095:138-141. |
| APA | Duan, Mingyu,Qin, Li,Zhong, Dafang,&Zhang, Peng.(2018).Identification of novel ondansetron metabolites using LC/MSn and NMR.JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,1095,138-141. |
| MLA | Duan, Mingyu,et al."Identification of novel ondansetron metabolites using LC/MSn and NMR".JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 1095(2018):138-141. |
入库方式： OAI收割
来源：上海药物研究所
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