Recent developments on synthesis and biological activities of gamma-carboline
文献类型：期刊论文
| 作者 | Dai, Jiangkun2; Dan, Wenjia2; Zhang, Yunyun2; Wang, Junru1,2 |
| 刊名 | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
 |
| 出版日期 | 2018-09-05 |
| 卷号 | 157页码:447-461 |
| 关键词 | gamma-carbolines Synthesis Biological activity |
| ISSN号 | 0223-5234 |
| DOI | 10.1016/j.ejmech.2018.08.015 |
| 文献子类 | Review |
| 英文摘要 | gamma-Carboline alkaloids are a family of natural and synthetic agents that have diverse bioactivities including antiviral, antibacterial, antifungal, antiparasitic, antitumor, anti-inflammatory, neuropharmacological activities and so on. They constitute an important class of pharmacologically active scaffolds that exhibit biological activity via diverse mechanisms. This review provides an update on the recent developments (2010-2017) in the synthesis and biological activities of these compounds. In cases where sufficient information is available, the mechanism and the structure-activity relationship (SAR) of biological activity are presented, and based on our expertise in the field and careful analysis of the recent literature, for the potential of gamma-carboline alkaloids as medicinal drugs is proposed. (C) 2018 Elsevier Masson SAS. All rights reserved. |
| WOS关键词 | RECEPTOR-BINDING AFFINITIES ; ISOCRYPTOLEPINE ANALOGS ; FACILE SYNTHESIS ; BOND FORMATION ; ACTIVE AMIDES ; ONE-POT ; DERIVATIVES ; DESIGN ; HETEROCYCLES ; EFFICIENT |
| 资助项目 | National Natural Science Foundation of China[81773603] ; Open Foundation of Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education (Northwest University, China)[00000000] ; State Key Laboratory of Drug Research[SIMM1705KF-09] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000447480000033 |
| 出版者 | ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279588]  |
| 专题 | 新药研究国家重点实验室 中科院受体结构与功能重点实验室 |
| 通讯作者 | Wang, Junru |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China 2.Northwest A&F Univ, Coll Chem & Pharm, 22 Xinong Rd, Yangling 712100, Shaanxi, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Dai, Jiangkun,Dan, Wenjia,Zhang, Yunyun,et al. Recent developments on synthesis and biological activities of gamma-carboline[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2018,157:447-461. |
| APA | Dai, Jiangkun,Dan, Wenjia,Zhang, Yunyun,&Wang, Junru.(2018).Recent developments on synthesis and biological activities of gamma-carboline.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,157,447-461. |
| MLA | Dai, Jiangkun,et al."Recent developments on synthesis and biological activities of gamma-carboline".EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 157(2018):447-461. |
入库方式： OAI收割
来源：上海药物研究所
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