Roles of Albumin-Binding Proteins in Cancer Progression and Biomimetic Targeted Drug Delivery
文献类型：期刊论文
| 作者 | Zhao, Pengfei1,4; Wang, Yonghui4; Wu, Aihua4; Rao, Yuefeng2; Huang, Yongzhuo3,4
|
| 刊名 | CHEMBIOCHEM
 |
| 出版日期 | 2018-09-04 |
| 卷号 | 19期号:17页码:1796-1805 |
| 关键词 | albumin-binding proteins biomimetic delivery cancer drug delivery nutrient transporters |
| ISSN号 | 1439-4227 |
| DOI | 10.1002/cbic.201800201 |
| 文献子类 | Review |
| 英文摘要 | Nutrient transporters have attracted significant attention for their promising application in biomimetic delivery. Due to the active consumption of nutrients, cancer cells generally overexpress nutrient transporters to meet their increased need for energy and materials. For example, albumin-binding proteins (ABPs) are highly overexpressed in malignant cells, stromal cells, and tumor vessel endothelial cells responsible for albumin uptake. ABP (e.g., SPARC) is a promising target for tumor-specific drug delivery, and albumin has been widely used as a biomimetic delivery carrier. Apart from the transportation function, ABPs are closely associated with neoplasia, invasion, and metastasis. Herein, a summary of the roles of ABP in cancer progression and the application of albumin-based biomimetic tumor-targeted delivery through the ABP pathway is presented. |
| WOS关键词 | CONFORMATIONALLY MODIFIED ALBUMINS ; NUCLEAR RIBONUCLEOPROTEIN-K ; BLOOD-BRAIN-BARRIER ; CELL LUNG-CANCER ; SPARC EXPRESSION ; CAPILLARY-PERMEABILITY ; PANCREATIC-CANCER ; ENDOTHELIAL-CELLS ; POOR-PROGNOSIS ; IN-VIVO |
| 资助项目 | 973 Program, P.R. China[2014CB931900] ; NFSC[81422048] ; NFSC[81673382] ; Strategic Priority Research Program of CAS[XDA12050307] ; National Special Project for Significant New Drugs Development[2018ZX09711002-010-002] ; CAS Scientific Research and Equipment Development Project[YZ201437] ; Fudan-SIMM Joint Research Fund[FU-SIMM20174009] ; Natural Science Foundation of Zhejiang Province, P.R. China[LY17H310002] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000443557100001 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279590]  |
| 专题 | 药物制剂研究中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Huang, Yongzhuo |
| 作者单位 | 1.Zhejiang Acad Med Sci, 182 Tianmushan Rd, Hangzhou 310013, Zhejiang, Peoples R China; 2.Zhejiang Univ, Affiliated Hosp 1, Coll Med, Hangzhou 310003, Zhejiang, Peoples R China; 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 501 Haike Rd, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Zhao, Pengfei,Wang, Yonghui,Wu, Aihua,et al. Roles of Albumin-Binding Proteins in Cancer Progression and Biomimetic Targeted Drug Delivery[J]. CHEMBIOCHEM,2018,19(17):1796-1805. |
| APA | Zhao, Pengfei,Wang, Yonghui,Wu, Aihua,Rao, Yuefeng,&Huang, Yongzhuo.(2018).Roles of Albumin-Binding Proteins in Cancer Progression and Biomimetic Targeted Drug Delivery.CHEMBIOCHEM,19(17),1796-1805. |
| MLA | Zhao, Pengfei,et al."Roles of Albumin-Binding Proteins in Cancer Progression and Biomimetic Targeted Drug Delivery".CHEMBIOCHEM 19.17(2018):1796-1805. |
入库方式： OAI收割
来源：上海药物研究所
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