Flabellipparicine, a Flabelliformide-Apparicine-Type Bisindole Alkaloid from Tabernaemontana divaricata
文献类型：期刊论文
| 作者 | Cai, You-Sheng5,6; Sarotti, Ariel M.1; Zhou, Ting-Lan5; Huang, Rong5; Qiu, Guofu5; Tian, Congkui2; Miao, Ze-Hong3; Mandi, Attila4; Kurtan, Tibor4; Cao, Shugeng6 |
| 刊名 | JOURNAL OF NATURAL PRODUCTS
 |
| 出版日期 | 2018-09 |
| 卷号 | 81期号:9页码:1976-1983 |
| ISSN号 | 0163-3864 |
| DOI | 10.1021/acs.jnatprod.8b00191 |
| 文献子类 | Article |
| 英文摘要 | Four new monoterpenoid bisindole alkaloids, flabellipparicine (1), 19,20-dihydrovobparicine (2), 10'-demethoxy-19,20-dihydrovobatensine D (3), and 3'-(2-oxopropyl)ervahanine A (4), and 10 known monoterpenoid indole alkaloids were isolated from the stems of Tabernaemontana divaricata. All structures were elucidated based on spectroscopic methods, and the absolute configuration of 1 was established using conformational analysis and TDDFT-ECD calculation of selected stereoisomers. Compound 1 represents the first flabelliformide-apparicine-type bisindole alkaloid, in which the flabelliformide-like unit connects to the apparicine-like unit with a C-3-C-22' bond and an N-1-C-16' bond to form an uncommon five-membered ring between the two monomers. All alkaloids were evaluated for their cytotoxicity against two human cancer cell lines, MCF-7 and A-549. Compounds 2, 4, and 14 exhibited cytotoxicity against MCF-7 and A-549 with IC50 values in the range of 2 nM to 8 mu M. |
| WOS关键词 | INDOLE ALKALOIDS ; ABSOLUTE-CONFIGURATION |
| 资助项目 | National Natural Science Foundation of China[21402146] ; National Key R & D Program of China[2018YFC0311002] ; Natural Science Foundation of Hubei Province[2015CFB421] ; open project of Hubei Key Laboratory of Purification and Application of Plant Anti-Cancer Ingredients[HLPAI2014001] ; EU[00000000] ; European Regional Development Fund[GINOP-2.3.2-15-2016-00008] |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000446276600008 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279592]  |
| 专题 | 药理学第一研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Cai, You-Sheng; Cao, Shugeng; Yang, Sheng-Ping |
| 作者单位 | 1.Univ Nacl Rosario, Fac Ciencias Bioquim & Farmaceut, Inst Quim Rosario, CONICET, Suipacha 531, RA-2000 Rosario, Santa Fe, Argentina; 2.Hubei Univ Nationalities, Wuling Mt Inst Nat Med, Key Lab Biol Resources Protect & Utilizat Hubei P, 39 Xueyuan Rd, Enshi 445000, Peoples R China; 3.Chinese Acad Sci, Inst Mat Med, State Key Lab Drug Res, Zu Chong Zhi Rd 555,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China; 4.Univ Debrecen, Dept Organ Chem, POB 400, H-4002 Debrecen, Hungary 5.Wuhan Univ, Sch Pharmaceut Sci, Inst TCM & Nat Prod, 185 Donghu Rd, Wuhan 430071, Hubei, Peoples R China; 6.Univ Hawaii Hilo, Daniel K Inouye Coll Pharm, Dept Pharmaceut Sci, 200 West Kawili St, Hilo, HI 96720 USA; |
| 推荐引用方式 GB/T 7714 | Cai, You-Sheng,Sarotti, Ariel M.,Zhou, Ting-Lan,et al. Flabellipparicine, a Flabelliformide-Apparicine-Type Bisindole Alkaloid from Tabernaemontana divaricata[J]. JOURNAL OF NATURAL PRODUCTS,2018,81(9):1976-1983. |
| APA | Cai, You-Sheng.,Sarotti, Ariel M..,Zhou, Ting-Lan.,Huang, Rong.,Qiu, Guofu.,...&Yang, Sheng-Ping.(2018).Flabellipparicine, a Flabelliformide-Apparicine-Type Bisindole Alkaloid from Tabernaemontana divaricata.JOURNAL OF NATURAL PRODUCTS,81(9),1976-1983. |
| MLA | Cai, You-Sheng,et al."Flabellipparicine, a Flabelliformide-Apparicine-Type Bisindole Alkaloid from Tabernaemontana divaricata".JOURNAL OF NATURAL PRODUCTS 81.9(2018):1976-1983. |
入库方式： OAI收割
来源：上海药物研究所
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