Genomic Heterogeneity and the Small Renal Mass
文献类型：期刊论文
| 作者 | Ueno, Daiki3; Xie, Zuoquan3,4 ; Boeke, Marta3; Syed, Jamil3; Nguyen, Kevin A.3; McGillivray, Patrick3; Adeniran, Adebowale5; Humphrey, Peter5; Dancik, Garrett M.1; Kluger, Yuval5
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| 刊名 | CLINICAL CANCER RESEARCH
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| 出版日期 | 2018-09-01 |
| 卷号 | 24期号:17页码:4137-4144 |
| ISSN号 | 1078-0432 |
| DOI | 10.1158/1078-0432.CCR-18-0214 |
| 文献子类 | Article |
| 英文摘要 | Purpose: Tumor heterogeneity may represent a barrier to preoperative genomic characterization by needle biopsy in clear cell renal cell carcinoma (ccRCC). The extent of heterogeneity in small renal tumors remains unknown. Therefore, we set out to evaluate heterogeneity in resected large and small renal tumors. Experimental Design: We conducted a study from 2013 to 2016 that evaluated 47 consecutive ccRCC tumors resected during radical or partial nephrectomy. Cases were designated as small (<4 cm) and large (>7 cm) tumors, Each tumor had three regions sampled. Copy-number variation (CNV) was assessed and gene expression analysis was performed to characterize the dear-cell A and B (ccA/ccB) profile and the cell-cycle progression (CCP) score. Genomic heterogeneity between three regions was evaluated using CNV subdonal events, regional expression profiles, and correlation between gene expression. Results: Twenty-three small and 24 large tumors were analyzed. Total CNVs and subdonal CNVs events were less frequent in small tumors (P < 0.001). Significant gene expression heterogeneity was observed for both CCP scores and ccA/ccB classifications. Larger tumors had more variance in CCP scores (P = 0.026). The distribution of ccA/ccB differed between small and large tumors with mixed ccA/ccB tumors occurring more frequently in the larger tumors (P = 0.024). Analysis of five mixed tumors (with both ccA/ccB regions) demonstrated the more aggressive ccB phenotype had greater CNV events (P = 0.014). Conclusions: Small renal tumors have much less genomic complexity and fewer subdonal events. Pretreatment genomic characterization with single-needle biopsy in small tumors may be useful to assess biologic potential and may influence therapy. (C)2018 AACR. |
| WOS关键词 | CELL CARCINOMA ; MOLECULAR SUBTYPES ; INTRATUMOR HETEROGENEITY ; NATURAL-HISTORY ; KIDNEY CANCER ; EVOLUTION ; BIOPSY ; IMPACT |
| 资助项目 | NIH[1K08CA207845-01] ; NIH[KL2 TR000140] ; NIH[R-01 CA158167] ; NIH[K24CA172123] |
| WOS研究方向 | Oncology |
| 语种 | 英语 |
| WOS记录号 | WOS:000444040400011 |
| 出版者 | AMER ASSOC CANCER RESEARCH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279595]  |
| 专题 | 药理学第一研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Shuchl, Brian |
| 作者单位 | 1.Eastern Connecticut Univ, Comp Sci Dept, Willmantic, CT USA; 2.Yale Sch Med, Dept Med Oncol, New Haven, CT USA 3.Yale Sch Med, Dept Urol, New Haven, CT USA; 4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Div Antitumor Pharmacol, Shanghai, Peoples R China; 5.Yale Sch Med, Dept Pathol, New Haven, CT USA; |
| 推荐引用方式 GB/T 7714 | Ueno, Daiki,Xie, Zuoquan,Boeke, Marta,et al. Genomic Heterogeneity and the Small Renal Mass[J]. CLINICAL CANCER RESEARCH,2018,24(17):4137-4144. |
| APA | Ueno, Daiki.,Xie, Zuoquan.,Boeke, Marta.,Syed, Jamil.,Nguyen, Kevin A..,...&Shuchl, Brian.(2018).Genomic Heterogeneity and the Small Renal Mass.CLINICAL CANCER RESEARCH,24(17),4137-4144. |
| MLA | Ueno, Daiki,et al."Genomic Heterogeneity and the Small Renal Mass".CLINICAL CANCER RESEARCH 24.17(2018):4137-4144. |
入库方式： OAI收割
来源：上海药物研究所
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