Enhancement of Glucose Utilization by Loesenerine through AMPK Activation in Myotubes
文献类型：期刊论文
| 作者 | Wang, Luo-Na3; Jiang, Hao-Wen2; Li, Jin-Long1; Li, Jing-Ya2
|
| 刊名 | CHEMICAL & PHARMACEUTICAL BULLETIN
 |
| 出版日期 | 2018-09 |
| 卷号 | 66期号:9页码:885-886 |
| 关键词 | loesenerine spermidine alkaloid AMP-activated protein kinase activation glucose uptake |
| ISSN号 | 0009-2363 |
| DOI | 10.1248/cpb.c18-00253 |
| 文献子类 | Article |
| 英文摘要 | Type 2 diabetes is characterized by hyperglycemia derived from insulin resistance in periphery tissue. Effects of skeletal muscle on glucose disposal are closely related to insulin resistance. The potential effects on mitochondrial function of loesenerine, a macrocyclic spermidine alkaloid from the aerial part of Euonymus fortunei (TURCZ.) HAND.-MAZZ were observed after a high-throughout screening based on mitochondrial membrane potential (MMP) assay. Further pharmacological studies revealed that loesenerine activates AMP-activated protein kinase (AMPK) pathway through increasing ADP/ATP ratio by inhibiting mitochondrial respiration. In addition, loesenerine induced 1.07-, 1.14-, and 1.22-fold increment of glucose uptake in C2C12 cells at the concentrations of 20, 40 and 80 mu mol/L, respectively. Meanwhile, incubated with loesenerine for 12 h increased glucose consumption in a dose-dependent manner in C2C12 cells. This is the first report that macrocyclic spermidine alkaloid possesses potential hypoglycemic activity in vitro. |
| WOS关键词 | SKELETAL-MUSCLE ; PROTEIN ; CELLS |
| WOS研究方向 | Pharmacology & Pharmacy ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000443531200008 |
| 出版者 | PHARMACEUTICAL SOC JAPAN |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279598]  |
| 专题 | 国家新药筛选中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Li, Jing-Ya |
| 作者单位 | 1.Nantong Univ, Sch Pharm, 19 Qixiu Rd, Nantong 226001, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 3.Nanchang Univ, Sch Life Sci, 999 Xuefu Ave, Nanchang 330031, Jiangxi, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Wang, Luo-Na,Jiang, Hao-Wen,Li, Jin-Long,et al. Enhancement of Glucose Utilization by Loesenerine through AMPK Activation in Myotubes[J]. CHEMICAL & PHARMACEUTICAL BULLETIN,2018,66(9):885-886. |
| APA | Wang, Luo-Na,Jiang, Hao-Wen,Li, Jin-Long,&Li, Jing-Ya.(2018).Enhancement of Glucose Utilization by Loesenerine through AMPK Activation in Myotubes.CHEMICAL & PHARMACEUTICAL BULLETIN,66(9),885-886. |
| MLA | Wang, Luo-Na,et al."Enhancement of Glucose Utilization by Loesenerine through AMPK Activation in Myotubes".CHEMICAL & PHARMACEUTICAL BULLETIN 66.9(2018):885-886. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。