New podolactones from the seeds of Podocarpus nagi and their anti-inflammatory effect
文献类型：期刊论文
| 作者 | Feng, Zhe-Ling2,3; Zhang, Tian3; Liu, Jing-Xin3; Chen, Xiu-Ping3; Gan, Li-She1; Ye, Yang2 ; Lin, Li-Gen2,3
|
| 刊名 | JOURNAL OF NATURAL MEDICINES
 |
| 出版日期 | 2018-09 |
| 卷号 | 72期号:4页码:882-889 |
| 关键词 | Podocarpus nagi Podolactones Anti-inflammation NO production NF-kappa B |
| ISSN号 | 1340-3443 |
| DOI | 10.1007/s11418-018-1219-5 |
| 文献子类 | Article |
| 英文摘要 | Podolactones are a class of structural diverse diterpenoid lactones, mainly isolated from the Podocarpus species. Several bioactivities have been disclosed for podolactones, including cytotoxicity and anti-atherosclerosis. In this study, the seeds of P. nagi were isolated by comprehensive chromatographic methods to obtain three new podolatones, named nagilactone B 1-O-beta-d-glucoside (1), nagilactone N3 3-O-beta-d-glucoside (2), and 2-epinagilactone B (3), as well as a known compound, nagilactone B (4). Their structures were determined by analyses of NMR and HRESIMS data. Compounds 1 and 2 significantly inhibited nitric oxide (NO) production on LPS-stimulated RAW264.7 macrophages, with IC50 values of 0.18 +/- 0.04 and 0.53 +/- 0.03 mu M, respectively. Indomethacin (IC50 4.21 +/- 0.32 mu M) was used as a positive control. Compound 1 suppressed the expression of inducible NO synthase (iNOS) in a concentration-dependent manner, mediating through inhibiting nuclear factor-kappa B (NF-kappa B) activity. This is the first report regarding the anti-inflammatory effect of podolactones, which could be potential anti-inflammatory agents. |
| WOS关键词 | NOR-DITERPENOID DILACTONES ; NORDITERPENOIDS ; EXTRACT |
| 资助项目 | Science and Technology Development Fund, Macao S.A.R[FDCT 102/2017/A] ; Research Fund of University of Macau[MYRG2017-00109-ICMS] ; State Key Laboratory of Drug Research[SIMM1803KF-16] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000441557000007 |
| 出版者 | SPRINGER JAPAN KK |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279603]  |
| 专题 | 新药研究国家重点实验室 中科院受体结构与功能重点实验室 |
| 通讯作者 | Lin, Li-Gen |
| 作者单位 | 1.Zhejiang Univ, Coll Pharmaceut Sci, 866 Yuhangtang Rd, Hangzhou 310058, Zhejiang, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China; 3.Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Ave Univ, Taipa 999078, Macau, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Feng, Zhe-Ling,Zhang, Tian,Liu, Jing-Xin,et al. New podolactones from the seeds of Podocarpus nagi and their anti-inflammatory effect[J]. JOURNAL OF NATURAL MEDICINES,2018,72(4):882-889. |
| APA | Feng, Zhe-Ling.,Zhang, Tian.,Liu, Jing-Xin.,Chen, Xiu-Ping.,Gan, Li-She.,...&Lin, Li-Gen.(2018).New podolactones from the seeds of Podocarpus nagi and their anti-inflammatory effect.JOURNAL OF NATURAL MEDICINES,72(4),882-889. |
| MLA | Feng, Zhe-Ling,et al."New podolactones from the seeds of Podocarpus nagi and their anti-inflammatory effect".JOURNAL OF NATURAL MEDICINES 72.4(2018):882-889. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。