Traceable Bioinspired Nanoparticle for the Treatment of Metastatic Breast Cancer via NIR-Trigged Intracellular Delivery of Methylene Blue and Cisplatin
文献类型：期刊论文
| 作者 | Zhai, Yihui2,3; Ran, Wei2,3; Su, Jinghan2,3; Lang, Tianqun2,3; Meng, Jia2,3; Wang, Guanru2; Zhang, Pengcheng2,3 ; Li, Yaping1,2,3
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| 刊名 | ADVANCED MATERIALS
 |
| 出版日期 | 2018-08-23 |
| 卷号 | 30期号:34 |
| 关键词 | bioinspired nanoparticles cytotoxic T lymphocytes metastasis triple-negative breast cancer tumor penetration |
| ISSN号 | 0935-9648 |
| DOI | 10.1002/adma.201802378 |
| 文献子类 | Article |
| 英文摘要 | Cytotoxic T lymphocyte (CTL) eliminates abnormal cells through target recognition-triggered intracellular toxin delivery. Chimeric antigen receptor T-cell improves cancer cell recognition of CTL, but its effectiveness and safety in solid tumor treatment are still hampered by poor tumor infiltration, suppressive tumor microenvironment, and severe on-target off-tumor toxicity. Given the functionality and challenges of CTL in cancer therapy, herein, a CTL-inspired nanovesicle (MPV) with a cell membrane-derived shell and a methylene blue (MB) and cisplatin (Pt) loaded gelatin nanogel core is created. The MPV generates contrast for tumor photoacoustic imaging, and produces hyperthermia upon laser irradiation, enabling photothermal imaging and deep tumor penetration. Meanwhile, it releases MB and Pt, and then delivers them into the cytosol of cancer cells, which process can be visualized by imaging the recovery of MB-derived fluorescence. The localized hyperthermia, photodynamic therapy, and chemotherapy together kill 4T1 breast cancer cells effectively, resulting in primary tumor regression and 97% inhibition of pulmonary metastasis, without significant toxicity to the animals. Taken together, the MPV shows tumor-specific and stimuli-triggered intracellular toxin delivery with advantages in traceable accumulation and activation, high tumor penetration, and triple combination therapy, and thus can be an effective nanomedicine for combating metastatic breast cancer. |
| WOS关键词 | MEMBRANE-CAMOUFLAGED NANOPARTICLES ; PHOTOTRIGGERED LOCAL-ANESTHESIA ; CHIMERIC ANTIGEN RECEPTOR ; B-CELL MALIGNANCIES ; RED-BLOOD-CELLS ; ARTIFICIAL CELLS ; DRUG-RELEASE ; T-CELLS ; CARBON NANOPARTICLES ; TUMOR PENETRATION |
| 资助项目 | National Natural Science Foundation of China[81521005] ; National Natural Science Foundation of China[81630052] ; National Natural Science Foundation of China[81690265] ; National Natural Science Foundation of China[81671808] ; Key scientific research program of CAS[QYZDJ-SSW-SMC020] ; Youth Innovation Promotion Association of CAS[2017335] |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:000442206400020 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279612]  |
| 专题 | 药物制剂研究中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Zhang, Pengcheng; Li, Yaping |
| 作者单位 | 1.Yantai Univ, Sch Pharm, 30 Qingquan Rd, Yantai 264005, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res & Ctr Pharmaceut, 501 Haike Rd, Shanghai 201203, Peoples R China; 3.Univ Chinese Acad Sci, Sch Pharm, 19 Yuquan Rd, Beijing 100049, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Zhai, Yihui,Ran, Wei,Su, Jinghan,et al. Traceable Bioinspired Nanoparticle for the Treatment of Metastatic Breast Cancer via NIR-Trigged Intracellular Delivery of Methylene Blue and Cisplatin[J]. ADVANCED MATERIALS,2018,30(34). |
| APA | Zhai, Yihui.,Ran, Wei.,Su, Jinghan.,Lang, Tianqun.,Meng, Jia.,...&Li, Yaping.(2018).Traceable Bioinspired Nanoparticle for the Treatment of Metastatic Breast Cancer via NIR-Trigged Intracellular Delivery of Methylene Blue and Cisplatin.ADVANCED MATERIALS,30(34). |
| MLA | Zhai, Yihui,et al."Traceable Bioinspired Nanoparticle for the Treatment of Metastatic Breast Cancer via NIR-Trigged Intracellular Delivery of Methylene Blue and Cisplatin".ADVANCED MATERIALS 30.34(2018). |
入库方式： OAI收割
来源：上海药物研究所
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