Design and Synthesis of Pyrophosphate-Targeting Vancomycin Derivatives for Combating Vancomycin-Resistant Enterococci
文献类型：期刊论文
| 作者 | Guan, Dongliang1,2; Chen, Feifei1; Faridoon1,2; Liu, Junjie1,3; Li, Jian1,2; Lan, Lefu1,2,4 ; Huang, Wei1,2,5
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| 刊名 | CHEMMEDCHEM
 |
| 出版日期 | 2018-08-20 |
| 卷号 | 13期号:16页码:1644-1657 |
| ISSN号 | 1860-7179 |
| 关键词 | antibacterial activity click chemistry Mannich reaction pyrophosphate vancomycin |
| DOI | 10.1002/cmdc.201800252 |
| 文献子类 | Article |
| 英文摘要 | As the last resort for intractable Gram-positive bacterial infections, vancomycin is losing efficacy with the emergence of vancomycin-resistant bacteria, especially vancomycin-resistant Enterococci (VRE). To combat this threat, we rationally designed and synthesized 39 novel vancomycin derivatives by respective or combined modifications using metal-chelating, lipophilic, and galactose-attachment strategies for extensive structure-activity relationship (SAR) analysis. In a proposed mechanism, the conjugation of dipicolylamine on the seventh amino acid resorcinol position or C-terminus endowed the vancomycin backbone with binding capacity for the pyrophosphate moiety in lipidII while maintaining the intrinsic binding affinity for the dipeptide terminus of the bacterial cell wall peptidoglycan precursor. The in vitro antibacterial activities were evaluated, and the optimal compounds indicated 16- to 1024-fold higher activity against VRE than that of vancomycin. Compound 11b (3,5-bis(dipicolylaminomethyl)tyrosine [1,2,3]triazolylmethoxylethyoxyl ethylaminomethyl-N-decylvancomycin) was found to have particularly potent activity against VRE through synergistic effects brought about by combining two peripheral modifications. |
| WOS关键词 | GRAM-POSITIVE INFECTIONS ; STAPHYLOCOCCUS-AUREUS ; SELECTIVE RECOGNITION ; TETRAZOLIUM SALT ; CELL VIABILITY ; LIPOGLYCOPEPTIDE ; BACTERIA ; WATER ; TELAVANCIN ; COMPLEXES |
| 资助项目 | National Natural Science Foundation of China (NNSFC)[21572244] ; SIMM institute fund[CASIMM0120162014] ; SIMM institute fund[CASIMM0120164007] ; Youth Innovation Promotion Association of CAS[2017328] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| WOS记录号 | WOS:000442341900005 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279614]  |
| 专题 | 药理学第三研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 生物技术药物研发中心（筹） 药物安全性评价中心 |
| 通讯作者 | Lan, Lefu; Huang, Wei |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Ctr Excellence Mol Cell Sci, CAS Key Lab Receptor Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China; 2.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China; 3.Nanchang Univ, Dept Chem, 999 Xuefu Ave, Nanchang 330031, Jiangxi, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 5.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Biotherapeut Discovery Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Guan, Dongliang,Chen, Feifei,Faridoon,et al. Design and Synthesis of Pyrophosphate-Targeting Vancomycin Derivatives for Combating Vancomycin-Resistant Enterococci[J]. CHEMMEDCHEM,2018,13(16):1644-1657. |
| APA | Guan, Dongliang.,Chen, Feifei.,Faridoon.,Liu, Junjie.,Li, Jian.,...&Huang, Wei.(2018).Design and Synthesis of Pyrophosphate-Targeting Vancomycin Derivatives for Combating Vancomycin-Resistant Enterococci.CHEMMEDCHEM,13(16),1644-1657. |
| MLA | Guan, Dongliang,et al."Design and Synthesis of Pyrophosphate-Targeting Vancomycin Derivatives for Combating Vancomycin-Resistant Enterococci".CHEMMEDCHEM 13.16(2018):1644-1657. |
入库方式： OAI收割
来源：上海药物研究所
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