CTC clusters induced by heparanase enhance breast cancer metastasis
文献类型：期刊论文
| 作者 | Wei, Rong-rui1; Sun, Dan-ni2; Yang, Hong2; Yan, Juan2; Zhang, Xiong2; Zheng, Xing-ling2; Fu, Xu-hong2; Geng, Mei-yu2 ; Huang, Xun2; Ding, Jian2
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| 刊名 | ACTA PHARMACOLOGICA SINICA
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| 出版日期 | 2018-08 |
| 卷号 | 39期号:8页码:1326-1337 |
| 关键词 | human breast cancer CTC clusters heparanase metastasis cell adhesion adhesion molecules suspension culture method |
| ISSN号 | 1671-4083 |
| DOI | 10.1038/aps.2017.189 |
| 文献子类 | Article |
| 英文摘要 | Aggregated metastatic cancer cells, referred to as circulating tumor cell (CTC) clusters, are present in the blood of cancer patients and contribute to cancer metastasis. However, the origin of CTC clusters, especially intravascular aggregates, remains unknown. Here, we employ suspension culture methods to mimic CTC cluster formation in the circulation of breast cancer patients. CTC clusters generated using these methods exhibited an increased metastatic potential that was defined by the overexpression of heparanase (HPSE). Heparanase induced FAK- and ICAM-1-dependent cell adhesion, which promoted intravascular cell aggregation. Moreover, knockdown of heparanase or inhibition of its activity with JG6, a heparanase inhibitor, was sufficient to block the formation of cell clusters and suppress breast cancer metastasis. Our data reveal that heparanase-mediated cell adhesion is critical for metastasis mediated by intravascular CTC clusters. We also suggest that targeting the function of heparanase in cancer cell dissemination might limit metastatic progression. |
| WOS关键词 | CIRCULATING TUMOR-CELLS ; FOCAL ADHESION KINASE ; INHIBITOR PI-88 ; LUNG-CANCER ; ANGIOGENESIS ; DISSEMINATION ; PLAKOGLOBIN ; MIGRATION ; MELANOMA ; SULFATE |
| 资助项目 | National Natural Science Foundation of China[81302791] ; Youth Innovation Promotion Association CAS[00000000] ; Chinese Academy of Sciences[XDA12020326] ; Shanghai Talent Development Funds[201663] |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| CSCD记录号 | CSCD:6309897 |
| WOS记录号 | WOS:000441241700008 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279633]  |
| 专题 | 药理学第一研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Huang, Xun; Ding, Jian |
| 作者单位 | 1.China Pharmaceut Univ, Dept New Drug Screening Ctr, Nanjing 210009, Jiangsu, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Div Antitumor Pharmacol, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wei, Rong-rui,Sun, Dan-ni,Yang, Hong,et al. CTC clusters induced by heparanase enhance breast cancer metastasis[J]. ACTA PHARMACOLOGICA SINICA,2018,39(8):1326-1337. |
| APA | Wei, Rong-rui.,Sun, Dan-ni.,Yang, Hong.,Yan, Juan.,Zhang, Xiong.,...&Ding, Jian.(2018).CTC clusters induced by heparanase enhance breast cancer metastasis.ACTA PHARMACOLOGICA SINICA,39(8),1326-1337. |
| MLA | Wei, Rong-rui,et al."CTC clusters induced by heparanase enhance breast cancer metastasis".ACTA PHARMACOLOGICA SINICA 39.8(2018):1326-1337. |
入库方式： OAI收割
来源：上海药物研究所
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