中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 上海药物研究所
  3. 中国科学院上海药物研究所
  4. 药物制剂研究中心
Bioengineered Macrophages Can Responsively Transform into Nanovesicles To Target Lung Metastasis

文献类型：期刊论文

作者Cao, Haiqiang1,2,3; Wang, Hong1,2,3; He, Xinyu1,2,3; Tan, Tao2,3; Hu, Haiyan2,3; Wang, Zhiwan1,2,3; Wang, Jing2,3; Li, Jie2,3; Zhang, Zhiwen2,3; Li, Yaping2,3,4
刊名NANO LETTERS
出版日期2018-08
卷号18期号:8页码:4762-4770
关键词Macrophage drug delivery cancer metastasis nanovesicles
ISSN号1530-6984
DOI10.1021/acs.nanolett.8b01236
文献子类Article
英文摘要Specific drug delivery to metastatic tumors remains a great challenge for antimetastasis therapy. We herein report a bioengineered macrophage-based delivery system (LD-MDS) that can be preferentially delivered to lung metastases and intelligently transformed into nanovesicles and secondary nanovesicles for antimetastasis therapy. LD-MDS was prepared by anchoring a legumain-specific propeptide of melittin (legM) and cytotoxic soravtansine (DM4) prodrug onto the membrane of living macrophages. LD-MDS is responsively activated by legumain protease and converted into DM4-loaded exosome-like nanovesicles (DENs), facilitating efficient internalization by metastatic 4T1 cancer cells and considerable cell death. Afterward, the damaged 4T1 cells can release secondary nanovesicles and free drug molecules to destroy neighboring cancer cells. In vivo, LD-MDS displays superior targeting efficiency for lung metastatic lesions with diameters less than 100 mu m and remarkably inhibits lung metastasis. This study provides a new opportunity to explore endogenous macrophages as living drug delivery vehicles with controlled drug release to target metastatic lung tumors.
WOS关键词MESENCHYMAL STEM-CELLS ; TUMOR-ASSOCIATED MACROPHAGES ; DRUG-DELIVERY ; PHOTOTHERMAL THERAPY ; BREAST-CANCER ; NANOPARTICLES ; MEMBRANE ; NANOCARRIERS ; DESIGN ; PROBE
资助项目National Basic Research Program of China[2015CB932103] ; National Natural Science Foundation of China[31771092] ; National Natural Science Foundation of China[81521005] ; National Natural Science Foundation of China[81690265] ; Youth Innovation Promotion Association of CAS[00000000] ; Shanghai Sailing Program[18YF1428400]
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种英语
WOS记录号WOS:000441478300020
出版者AMER CHEMICAL SOC
源URL[http://119.78.100.183/handle/2S10ELR8/279636]  
专题药物制剂研究中心
中科院受体结构与功能重点实验室
新药研究国家重点实验室
通讯作者Zhang, Zhiwen; Li, Yaping
作者单位1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China;
2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China;
3.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China;
4.Yantai Univ, Sch Pharm, Yantai 264005, Shandong, Peoples R China
推荐引用方式
GB/T 7714		 Cao, Haiqiang,Wang, Hong,He, Xinyu,et al. Bioengineered Macrophages Can Responsively Transform into Nanovesicles To Target Lung Metastasis[J]. NANO LETTERS,2018,18(8):4762-4770.
APA Cao, Haiqiang.,Wang, Hong.,He, Xinyu.,Tan, Tao.,Hu, Haiyan.,...&Li, Yaping.(2018).Bioengineered Macrophages Can Responsively Transform into Nanovesicles To Target Lung Metastasis.NANO LETTERS,18(8),4762-4770.
MLA Cao, Haiqiang,et al."Bioengineered Macrophages Can Responsively Transform into Nanovesicles To Target Lung Metastasis".NANO LETTERS 18.8(2018):4762-4770.

入库方式： OAI收割

来源：上海药物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。