Two new cytotoxic steroids from the Chinese soft coral Sinularia sp.
文献类型：期刊论文
| 作者 | Li, Song-Wei1,2; Chen, Wen-Ting2; Yao, Li-Gong2; Guo, Yue-Wei2
|
| 刊名 | STEROIDS
 |
| 出版日期 | 2018-08 |
| 卷号 | 136页码:17-21 |
| 关键词 | Sinularia Polyhydroxylated steroids Modified Mosher's method Cytotoxicity |
| ISSN号 | 0039-128X |
| DOI | 10.1016/j.steroids.2018.05.009 |
| 文献子类 | Article |
| 英文摘要 | Two new steroids, ximaosteroid E (1) and ximaosteroid F (2), along with two known related compounds (3 and 4), were isolated from the Chinese soft coral Sinularia sp. Notably, 1 possesses an uncommon dihydrofuran group. Their structures were established from extensive spectroscopic analyses and comparisons of their spectral data with those reported in the literature. The absolute configuration of 2 was determined by applying the modified Mosher's method. In bioassay, compounds 1, 2, and 4 showed significant cytotoxicity against the HL-60 tumor cell line with IC50 values of 1.79, 4.03 and 0.69 mu M, respectively. |
| WOS关键词 | POLYOXYGENATED STEROIDS ; PHARMACOLOGICAL-ACTIVITIES ; POLYHYDROXYLATED STEROIDS |
| 资助项目 | Natural Science Foundation of China[81520108028] ; Natural Science Foundation of China[21672230] ; Natural Science Foundation of China[81603022] ; NSFC-Shandong Joint Fund for Marine Science Research Centers[U1606403] ; SCTSM[15431901000] ; SKLDR/SIMM[SIMM 1705ZZ-01] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Endocrinology & Metabolism |
| 语种 | 英语 |
| WOS记录号 | WOS:000438323700003 |
| 出版者 | ELSEVIER SCIENCE INC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279648]  |
| 专题 | 天然药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Guo, Yue-Wei |
| 作者单位 | 1.Nanchang Univ, Sch Pharm, Nanchang 330006, Jiangxi, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Materia Med, State Key Lab Drug Res, 555 Chong Zhi Rd,Zhangiiang Hitech Pk, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Song-Wei,Chen, Wen-Ting,Yao, Li-Gong,et al. Two new cytotoxic steroids from the Chinese soft coral Sinularia sp.[J]. STEROIDS,2018,136:17-21. |
| APA | Li, Song-Wei,Chen, Wen-Ting,Yao, Li-Gong,&Guo, Yue-Wei.(2018).Two new cytotoxic steroids from the Chinese soft coral Sinularia sp..STEROIDS,136,17-21. |
| MLA | Li, Song-Wei,et al."Two new cytotoxic steroids from the Chinese soft coral Sinularia sp.".STEROIDS 136(2018):17-21. |
入库方式： OAI收割
来源：上海药物研究所
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