Cytotoxic and other withanolides from aeroponically grown Physalis philadelphica
文献类型：期刊论文
| 作者 | Xu, Ya-Ming2; Wijeratne, E. M. Kithsiri2; Brooks, Alan D.1,3; Tewary, Poonam1,3; Xuan, Li-Jiang4 ; Wang, Wen-Qiong4; Sayers, Thomas J.1,3; Gunatilaka, A. A. Leslie2
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| 刊名 | PHYTOCHEMISTRY
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| 出版日期 | 2018-08 |
| 卷号 | 152页码:174-181 |
| 关键词 | Physalis philadelphica Solanaceae Aeroponic cultivation Chemical investigation Withanolides Cytotoxic activity |
| ISSN号 | 0031-9422 |
| DOI | 10.1016/j.phytochem.2018.04.018 |
| 文献子类 | Article |
| 英文摘要 | Eleven withanolides including six previously undescribed compounds, 16 beta-hydroxyixocarpanolide, 24,25-dihydroexodeconolide C, 16,17-dehydro-24-epi-dioscorolide A, 17-epi-philadelphicalactone A, 16-deoxyphiladelphicalactone C, and 4-deoxyixocarpalactone A were isolated from aeroponically grown Physalis philadelphica. Structures of these withanolides were elucidated by the analysis of their spectroscopic (HRMS, 1D and 2D NMR, ECD) data and comparison with published data for related withanolides. Cytotoxic activity of all isolated compounds was evaluated against a panel of five human tumor cell lines (LNCaP, ACHN, UO-31, M14 and SK-MEL-28), and normal (HFF) cells. Of these, 17-epi-philadelphicalactone A, withaphysacarpin, philadelphicalactone C, and ixocarpalactone A exhibited cytotoxicity against ACHN, UO-31, M14 and SK-MEL-28, but showed no toxicity to HFF cells. (C) 2018 Elsevier Ltd All rights reserved. |
| WOS关键词 | PROSTATE-CANCER ; SELECTIVE CYTOTOXICITY ; QUINONE REDUCTASE ; ERGOSTANE-TYPE ; STEROIDS ; SOLANACEAE ; INDUCTION ; PERUVIANA ; POTENT ; CELLS |
| 资助项目 | Arizona Biomedical Research Commission[ADHS-16-162515] ; gs2:National Cancer Institute, National Institutes of Health[HHSN26120080001E] ; Intramural Research Program of NIH, Frederick National Lab, Center for Cancer Research[00000000] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Plant Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000437383300020 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279650]  |
| 专题 | 上海中药现代化研究中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Gunatilaka, A. A. Leslie |
| 作者单位 | 1.Natl Canc Inst Frederick, Canc & Inflammat Program, Frederick, MD 21702 USA; 2.Univ Arizona, Coll Agr & Life Sci, Sch Nat Resources & Environm, Nat Prod Ctr, 250 E Valencia Rd, Tucson, AZ 85706 USA; 3.Natl Canc Inst Frederick, Frederick Natl Lab Canc Res, Leidos Biomed Res Inc, Basic Res Program, Frederick, MD 21702 USA; 4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 501 Haike Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Ya-Ming,Wijeratne, E. M. Kithsiri,Brooks, Alan D.,et al. Cytotoxic and other withanolides from aeroponically grown Physalis philadelphica[J]. PHYTOCHEMISTRY,2018,152:174-181. |
| APA | Xu, Ya-Ming.,Wijeratne, E. M. Kithsiri.,Brooks, Alan D..,Tewary, Poonam.,Xuan, Li-Jiang.,...&Gunatilaka, A. A. Leslie.(2018).Cytotoxic and other withanolides from aeroponically grown Physalis philadelphica.PHYTOCHEMISTRY,152,174-181. |
| MLA | Xu, Ya-Ming,et al."Cytotoxic and other withanolides from aeroponically grown Physalis philadelphica".PHYTOCHEMISTRY 152(2018):174-181. |
入库方式： OAI收割
来源：上海药物研究所
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