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Asymmetric Synthesis of 3,5-Disubstituted Prolines

文献类型：期刊论文

作者Zhao Liang1,2,3,4; Zhou Shengbin1,2,4; Tong Junhua1,2,3,4; Wang Jiang1,2,4; Liu Hong1,2,4
刊名CHINESE JOURNAL OF ORGANIC CHEMISTRY
出版日期2018-06-25
卷号38期号:6页码:1437-1446
关键词3,5-disubstituted proline Ni(II)-complex of glycine asymmetric Michael addition
ISSN号0253-2786
DOI10.6023/cjoc201712005
文献子类Article
英文摘要Highly diastereoselective Michael addition reactions of chiral Ni(II)-complex of glycine with alpha,beta-unsaturated ketones in the presence of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) and MeOH at ambient temperature were achieved. The operationally convenient procedure for preparation of the target products renders that this method is an attractive strategy for practical synthesis of 3,5-disubstituted prolines.
WOS关键词BETA-AMINO ACIDS ; CHIRAL NICKEL(II) GLYCINATE ; MICHAEL ADDITION-REACTIONS ; ALPHA-AMINO ; EFFICIENT SYNTHESIS ; NI(II) COMPLEX ; FACE DIASTEREOSELECTIVITY ; ALPHA,BETA-DIAMINO ACIDS ; KINETIC RESOLUTION ; ONE-POT
资助项目National Natural Science Foundation of China[81620108027] ; National Natural Science Foundation of China[21632008] ; National Natural Science Foundation of China[21672231] ; National Natural Science Foundation of China[21472209] ; Major Project of Chinese National Programs for Fundamental Research and Development[2015CB910304] ; Shanghai Science and Technology Development Fund[15QA1404400]
WOS研究方向Chemistry
语种英语
CSCD记录号CSCD:6274007
WOS记录号WOS:000440497100014
出版者SCIENCE PRESS
源URL[http://119.78.100.183/handle/2S10ELR8/279696]  
专题药物化学研究室
中科院受体结构与功能重点实验室
新药研究国家重点实验室
通讯作者Wang Jiang; Liu Hong
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China;
2.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China;
3.Univ Sci & Technol China, Nano Sci & Technol Inst, Suzhou 215123, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China;
推荐引用方式
GB/T 7714		 Zhao Liang,Zhou Shengbin,Tong Junhua,et al. Asymmetric Synthesis of 3,5-Disubstituted Prolines[J]. CHINESE JOURNAL OF ORGANIC CHEMISTRY,2018,38(6):1437-1446.
APA Zhao Liang,Zhou Shengbin,Tong Junhua,Wang Jiang,&Liu Hong.(2018).Asymmetric Synthesis of 3,5-Disubstituted Prolines.CHINESE JOURNAL OF ORGANIC CHEMISTRY,38(6),1437-1446.
MLA Zhao Liang,et al."Asymmetric Synthesis of 3,5-Disubstituted Prolines".CHINESE JOURNAL OF ORGANIC CHEMISTRY 38.6(2018):1437-1446.

入库方式： OAI收割

来源：上海药物研究所

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