Ligand-promoted ruthenium-catalyzed meta C-H chlorination of arenes using N-chloro-2,10-camphorsultam
文献类型：期刊论文
| 作者 | Fan, Zhoulong1,2,3; Lu, Heng4; Cheng, Zhen5; Zhang, Ao1,2,3,4
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| 刊名 | CHEMICAL COMMUNICATIONS
 |
| 出版日期 | 2018-06-14 |
| 卷号 | 54期号:47页码:6008-6011 |
| ISSN号 | 1359-7345 |
| DOI | 10.1039/c8cc03195a |
| 文献子类 | Article |
| 英文摘要 | A practical meta C-H chlorination protocol is established via a Ru(0)-catalyzed ortho-metalation strategy. The use of N-chloro-2,10-camphorsultam as a new chlorinating agent is crucial for the success of the current reaction and an N-heterocyclic carbene (NHC) ligand could significantly enhance the reactivity of the catalytic transformation. The mechanistic studies reveal that an unusual ortho C-H ruthenation relay process with ortho chlorination of the C-Ru bond is probably involved. |
| WOS关键词 | ORTHO-METALATION STRATEGY ; ARYL CHLORIDES ; REMOVABLE AUXILIARIES ; FUNCTIONALIZATION ; BROMINATION ; ALKYLATION ; NITRATION ; MONO ; REGIOSELECTIVITY ; DERIVATIVES |
| 资助项目 | Chinese NSF[81430080] ; Chinese NSF[81773565] ; National Program on Key Basic Research Project of China[2015CB910603] ; International Cooperative Program of the Chinese Academy of Sciences[GJHZ1622] ; Key Program of the Frontier Science of the Chinese Academy of Sciences[QYZDJ-SSW-SMC002] ; Shanghai Commission of Science and Technology[16XD1404600] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000434679500016 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279708]  |
| 专题 | 药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Zhang, Ao |
| 作者单位 | 1.Chinese Acad Sci, SIMM, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, SIMM, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China; 4.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China; 5.Stanford Univ, Dept Med, Sch Med, Mol Imaging Program Stanford, Stanford, CA 94305 USA |
| 推荐引用方式 GB/T 7714 | Fan, Zhoulong,Lu, Heng,Cheng, Zhen,et al. Ligand-promoted ruthenium-catalyzed meta C-H chlorination of arenes using N-chloro-2,10-camphorsultam[J]. CHEMICAL COMMUNICATIONS,2018,54(47):6008-6011. |
| APA | Fan, Zhoulong,Lu, Heng,Cheng, Zhen,&Zhang, Ao.(2018).Ligand-promoted ruthenium-catalyzed meta C-H chlorination of arenes using N-chloro-2,10-camphorsultam.CHEMICAL COMMUNICATIONS,54(47),6008-6011. |
| MLA | Fan, Zhoulong,et al."Ligand-promoted ruthenium-catalyzed meta C-H chlorination of arenes using N-chloro-2,10-camphorsultam".CHEMICAL COMMUNICATIONS 54.47(2018):6008-6011. |
入库方式： OAI收割
来源：上海药物研究所
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