Design, synthesis, and molecular docking study of 3H-imidazole[4,5-c]pyridine derivatives as CDK2 inhibitors
文献类型：期刊论文
| 作者 | Wu, Yi-Zhe2; Ying, Hua-Zhou2; Xu, Lei3,4; Cheng, Gang1; Chen, Jing1 ; Hu, Yong-Zhou2; Liu, Tao2; Dong, Xiao-Wu2
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| 刊名 | ARCHIV DER PHARMAZIE
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| 出版日期 | 2018-06 |
| 卷号 | 351期号:6 |
| 关键词 | cancer CDK2 inhibitor imidazo[4 5-c]pyridine targeted therapy |
| ISSN号 | 0365-6233 |
| DOI | 10.1002/ardp.201700381 |
| 文献子类 | Article |
| 英文摘要 | A novel series of imidazo[4,5-c]pyridine-based CDK2 inhibitors were designed from the structure of CYC202 via scaffold hopping strategy. These compounds were synthesized and biologically evaluated for their CDK2 inhibitory and in vitro anti-proliferation potential against cancer cell lines. Several compounds exhibited potent CDK2 inhibition with IC50 values of less than 1 mu M. The most potent compound 5b showed excellent CDK2 inhibitory (IC50=21nM) and in vitro anti-proliferation activity against three different cell lines (HL60, A549, and HCT116). The molecular docking and dynamic studies portrayed the potential binding mechanism between 5b and CDK2, and several key interactions between them were observed, which would be the reason for its potent CDK2 inhibitory and anti-proliferation activities. Therefore, the pyridin-3-ylmethyl moiety would serve as an excellent pharmacophore for the development of novel CDK2 inhibitors for targeted anti-cancer therapy. |
| WOS关键词 | CYCLIN-DEPENDENT KINASES ; CELL-CYCLE ; CANCER-THERAPY ; POTENT ; DISCOVERY ; TARGETS ; AGENTS |
| 资助项目 | National Natural Science Foundation of China[81673294] ; State Key Laboratory of Drug Research[SIMM1705KF-08] ; Key New Drug Creation and Manufacturing Program[2018ZX09711002-011-022] ; Science and Technology Planning Project of Zhejiang Province[2016C33067] |
| WOS研究方向 | Pharmacology & Pharmacy ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000434048300003 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279725]  |
| 专题 | 国家新药筛选中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Cheng, Gang; Liu, Tao; Dong, Xiao-Wu |
| 作者单位 | 1.Zhejiang Chinese Med Univ, Coll Pharmaceut Sci, Hangzhou 311402, Zhejiang, Peoples R China 2.Zhejiang Univ, ZJU ENS Joint Lab Med Chem, Zhejiang Prov Key Lab Anticanc Drug Res, Coll Pharmaceut Sci,Hangzhou Inst Innovat Med, Hangzhou 310058, Zhejiang, Peoples R China; 3.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Wu, Yi-Zhe,Ying, Hua-Zhou,Xu, Lei,et al. Design, synthesis, and molecular docking study of 3H-imidazole[4,5-c]pyridine derivatives as CDK2 inhibitors[J]. ARCHIV DER PHARMAZIE,2018,351(6). |
| APA | Wu, Yi-Zhe.,Ying, Hua-Zhou.,Xu, Lei.,Cheng, Gang.,Chen, Jing.,...&Dong, Xiao-Wu.(2018).Design, synthesis, and molecular docking study of 3H-imidazole[4,5-c]pyridine derivatives as CDK2 inhibitors.ARCHIV DER PHARMAZIE,351(6). |
| MLA | Wu, Yi-Zhe,et al."Design, synthesis, and molecular docking study of 3H-imidazole[4,5-c]pyridine derivatives as CDK2 inhibitors".ARCHIV DER PHARMAZIE 351.6(2018). |
入库方式： OAI收割
来源：上海药物研究所
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