The synthesis and antistaphylococcal activity of N-sulfonaminoethyloxime derivatives of dehydroabietic acid
文献类型：期刊论文
| 作者 | Zhang, Wen-Ming2; Yao, Yang3,4; Yang, Teng1,4; Wang, Xue-Ying2; Zhu, Zhen-Yun4; Xu, Wen-Tao2; Lin, Hai-Xia2; Gao, Zhao-Bing4 ; Zhou, Hu4; Yang, Cai-Guang4
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| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
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| 出版日期 | 2018-06-01 |
| 卷号 | 28期号:10页码:1943-1948 |
| 关键词 | Antistaphylococcal Multidrug-resistant Synthesis Oxime Dehydroabietic acid |
| ISSN号 | 0960-894X |
| DOI | 10.1016/j.bmcl.2018.03.062 |
| 文献子类 | Article |
| 英文摘要 | A series of N-sulfonaminoethyloxime derivatives of dehydroabietic acid were synthesized and investigated for their antibacterial activity against Staphylococcus aureus Newman strain and multidrug-resistant strains (NRS-1, NRS-70, NRS-100, NRS-108 and NRS-271). Most of the target compounds having chloro, bromo, trifluoromethyl phenyl moiety exhibited potent in vitro antistaphylococcal activity. The meta-CF3 phenyl derivative T23 showed the highest activity with MIC of 0.39-0.78 mu g/mL against S aureus Newman, while several analogues showed similar potent antibacterial activity with MIC values between 0.78 and 1.56 mu g/mL against five multidrug-resistant S. aureus. The stability of T35 in plasma of SD rat and the cellular cytotoxicity were also evaluated. (C) 2018 Elsevier Ltd. All rights reserved. |
| WOS关键词 | AROMATIC ABIETANE DITERPENOIDS ; STAPHYLOCOCCUS-AUREUS ; ANTIBACTERIAL ACTIVITY ; ANTIMICROBIAL ACTIVITY ; BIOLOGICAL-ACTIVITY ; TOTAROL ; BACTERIA ; DESIGN ; C-12 |
| 资助项目 | National Natural Science Foundation of China[81202402] ; National Natural Science Foundation of China[81661138004] ; State Key Laboratory of Drug Research[SIMM1501KF-11] ; Program of Shanghai Academic Research Leader[17XD1404400] |
| WOS研究方向 | Pharmacology & Pharmacy ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000432729000048 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279738]  |
| 专题 | 药理学第三研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Yang, Cai-Guang; Cui, Yong-Mei |
| 作者单位 | 1.Guizhou Univ, Ctr Res & Dev Fine Chem, Guiyang 550025, Guizhou, Peoples R China; 2.Shanghai Univ, Coll Sci, Innovat Drug Res Ctr, Dept Chem, Shanghai 200444, Peoples R China; 3.Shanghai Univ, Sch Life Sci, Shanghai 200444, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Wen-Ming,Yao, Yang,Yang, Teng,et al. The synthesis and antistaphylococcal activity of N-sulfonaminoethyloxime derivatives of dehydroabietic acid[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2018,28(10):1943-1948. |
| APA | Zhang, Wen-Ming.,Yao, Yang.,Yang, Teng.,Wang, Xue-Ying.,Zhu, Zhen-Yun.,...&Cui, Yong-Mei.(2018).The synthesis and antistaphylococcal activity of N-sulfonaminoethyloxime derivatives of dehydroabietic acid.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,28(10),1943-1948. |
| MLA | Zhang, Wen-Ming,et al."The synthesis and antistaphylococcal activity of N-sulfonaminoethyloxime derivatives of dehydroabietic acid".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 28.10(2018):1943-1948. |
入库方式： OAI收割
来源：上海药物研究所
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