Peptide-based nanoprobes for molecular imaging and disease diagnostics
文献类型：期刊论文
| 作者 | Zhang, Pengcheng2,3 ; Cui, Yonggang4; Anderson, Caleb F.5,6; Zhang, Chunli4; Li, Yaping2,3; Wang, Rongfu4; Cui, Honggang1,5,6,7,8
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| 刊名 | CHEMICAL SOCIETY REVIEWS
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| 出版日期 | 2018-05-21 |
| 卷号 | 47期号:10页码:3490-3529 |
| ISSN号 | 0306-0012 |
| DOI | 10.1039/c7cs00793k |
| 文献子类 | Review |
| 英文摘要 | Pathological changes in a diseased site are often accompanied by abnormal activities of various biomolecules in and around the involved cells. Identifying the location and expression levels of these biomolecules could enable early-stage diagnosis of the related disease, the design of an appropriate treatment strategy, and the accurate assessment of the treatment outcomes. Over the past two decades, a great diversity of peptide-based nanoprobes (PBNs) have been developed, aiming to improve the in vitro and in vivo performances of water-soluble molecular probes through engineering of their primary chemical structures as well as the physicochemical properties of their resultant assemblies. In this review, we introduce strategies and approaches adopted for the identification of functional peptides in the context of molecular imaging and disease diagnostics, and then focus our discussion on the design and construction of PBNs capable of navigating through physiological barriers for targeted delivery and improved specificity and sensitivity in recognizing target biomolecules. We highlight the biological and structural roles that low-molecular-weight peptides play in PBN design and provide our perspectives on the future development of PBNs for clinical translation. |
| WOS关键词 | CELL-PENETRATING PEPTIDES ; IRON-OXIDE NANOPARTICLES ; POSITRON-EMISSION-TOMOGRAPHY ; BLOOD-BRAIN-BARRIER ; SOMATOSTATIN-RECEPTOR SCINTIGRAPHY ; NEAR-INFRARED FLUORESCENCE ; ENHANCED RAMAN-SCATTERING ; IN-VIVO FLUORESCENCE ; DENSITY-LIPOPROTEIN RECEPTOR ; COPPER SULFIDE NANOPARTICLES |
| 资助项目 | National Natural Science Foundation of China[81521005] ; National Natural Science Foundation of China[81690265] ; National Natural Science Foundation of China[81671808] ; National Natural Science Foundation of China[30870729] ; National Natural Science Foundation of China[81071183] ; Youth Innovation Promotion Association of CAS[2017335] ; National Major Scientific Equipment Special Grant[2011YQ03011409] ; Twelfth "Five-Year'' Plan for Science & Technology Support[2014BAA03B03] ; W. W. Smith Charitable Trust[00000000] ; Johns Hopkins Discovery Award[00000000] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000432864500007 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279751]  |
| 专题 | 药物制剂研究中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Li, Yaping; Wang, Rongfu; Cui, Honggang |
| 作者单位 | 1.Johns Hopkins Univ, Sch Med, Dept Oncol, Baltimore, MD 21205 USA; 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 501 Haike Rd, Shanghai 201203, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, 501 Haike Rd, Shanghai 201203, Peoples R China; 4.Peking Univ, Hosp 1, Dept Nucl Med, 8 Xishiku Dajie, Beijing 100034, Peoples R China; 5.Johns Hopkins Univ, Dept Chem & Biomol Engn, 3400 North Charles St, Baltimore, MD 21218 USA; 6.Johns Hopkins Univ, Inst NanoBiotechnol, 3400 North Charles St, Baltimore, MD 21218 USA; 7.Johns Hopkins Univ, Dept Mat Sci & Engn, 3400 North Charles St, Baltimore, MD 21218 USA; 8.Johns Hopkins Univ, Sch Med, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21205 USA |
| 推荐引用方式 GB/T 7714 | Zhang, Pengcheng,Cui, Yonggang,Anderson, Caleb F.,et al. Peptide-based nanoprobes for molecular imaging and disease diagnostics[J]. CHEMICAL SOCIETY REVIEWS,2018,47(10):3490-3529. |
| APA | Zhang, Pengcheng.,Cui, Yonggang.,Anderson, Caleb F..,Zhang, Chunli.,Li, Yaping.,...&Cui, Honggang.(2018).Peptide-based nanoprobes for molecular imaging and disease diagnostics.CHEMICAL SOCIETY REVIEWS,47(10),3490-3529. |
| MLA | Zhang, Pengcheng,et al."Peptide-based nanoprobes for molecular imaging and disease diagnostics".CHEMICAL SOCIETY REVIEWS 47.10(2018):3490-3529. |
入库方式： OAI收割
来源：上海药物研究所
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