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Synthesis of 3,4-diarylsubstituted hexahydro-1H-indoles

文献类型：期刊论文

作者Zhou, Feilong1,2; Zhao, Erbao1,2; Yan, Ziqin1; Chen, Deheng1,3; Zhao, Yujun1
刊名TETRAHEDRON LETTERS
出版日期2018-05-09
卷号59期号:19页码:1871-1874
关键词Aziridine Hypersaturated indole Cation Allylic cation Cyclization
ISSN号0040-4039
DOI10.1016/j.tetlet.2018.04.008
文献子类Article
英文摘要Efficient syntheses of 3,4-diarylsubstituted hexahydro-1H-indoles in good yields with excellent diastere-oselectivities were achieved with a two-step protocol comprising an allylic cation mediated nucleophilic addition and an intramolecular cyclization reaction. The N-aryl sulfonyl protecting groups of cyclization products were readily removed to furnish free amines with retention of halogen substitutions and C-C double bonds. (C) 2018 Elsevier Ltd. All rights reserved.
WOS关键词MISCELLANEOUS ALKALOIDS ; BUILDING-BLOCKS ; SCELETIUM ; CONSTRUCTION ; AZIRIDINES ; INHIBITORS ; POTENT ; OCTAHYDROINDOLES ; AMARYLLIDACEAE ; IMIDAZOLE
资助项目National Natural Science Foundation of China[81673295] ; Chinese Academy of Sciences[XDA12020322] ; Shanghai Institute of Materia Medica startup-grant[00000000] ; Recruitment Program of Global Youth Experts (The 1000 Youth Talents Program)[00000000]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000431159000017
出版者PERGAMON-ELSEVIER SCIENCE LTD
源URL[http://119.78.100.183/handle/2S10ELR8/279764]  
专题药物化学研究室
中科院受体结构与功能重点实验室
新药研究国家重点实验室
通讯作者Zhao, Yujun
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China;
2.Univ Sci & Technol China, Nano Sci & Technol Inst, Suzhou 215123, Jiangsu, Peoples R China;
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Zhou, Feilong,Zhao, Erbao,Yan, Ziqin,et al. Synthesis of 3,4-diarylsubstituted hexahydro-1H-indoles[J]. TETRAHEDRON LETTERS,2018,59(19):1871-1874.
APA Zhou, Feilong,Zhao, Erbao,Yan, Ziqin,Chen, Deheng,&Zhao, Yujun.(2018).Synthesis of 3,4-diarylsubstituted hexahydro-1H-indoles.TETRAHEDRON LETTERS,59(19),1871-1874.
MLA Zhou, Feilong,et al."Synthesis of 3,4-diarylsubstituted hexahydro-1H-indoles".TETRAHEDRON LETTERS 59.19(2018):1871-1874.

入库方式： OAI收割

来源：上海药物研究所

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