Antibacterial sorbicillin and diketopiperazines from the endogenous fungus Penicillium sp GD6 associated Chinese mangrove Bruguiera gymnorrhiza
文献类型：期刊论文
| 作者 | Jiang Cheng-Shi1,2; Zhou Zhen-Fang1; Yang Xiao-Hong3; Lan Le-Fu1 ; Gu Yu-Cheng4; Ye Bo-Ping3; Guo Yue-Wei1
|
| 刊名 | CHINESE JOURNAL OF NATURAL MEDICINES
 |
| 出版日期 | 2018-05 |
| 卷号 | 16期号:5页码:358-365 |
| 关键词 | Mangrove Penicillium sp. Sorbicillin derivative Diketopiperazine alkaloids |
| ISSN号 | 2095-6975 |
| DOI | 10.1016/S1875-5364(18)30068-2 |
| 文献子类 | Article |
| 英文摘要 | One new sorbicillin derivative, 2-deoxy-sohirnone C (1), one new diketopiperazine alkaloid, 5S-hydroxynorvaline-S-Ile (2), and two naturally occurring diketopiperazines, 3S-hydroxylcyclo(S-Pro-S-Phe) (3) and cyclo(S-Phe-S-Gln) (4), together with three known compounds were isolated from the Chinese mangrove endophytic fungus Penicillium sp. GD6. Their structures were determined on the basis of extensive spectroscopic analyses and by comparison with literature data. The absolute configuration of 3-hydroxyl moiety in 3 was determined by Mosher's method, while the absolute stereochemistry of 2 and 4 was established by comparison with the CD spectra of natural and synthesized diketopiperazines. Compound 1 showed moderate antibacterial activity against Methicillin-resistant Staphylococcus aureus with a MIC value of 80 mu g.mL(-1). |
| WOS关键词 | ANALOGS ; INHIBITORS ; DESIGN |
| 资助项目 | Natural Science Foundation of China[81520108028] ; SCTSM Projects[14431901100] ; SCTSM Projects[15431901000] ; SKLDR/SIMM Project[SIMM1501ZZ-03] |
| WOS研究方向 | Integrative & Complementary Medicine ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| CSCD记录号 | CSCD:6247462 |
| WOS记录号 | WOS:000433996500006 |
| 出版者 | CHINESE JOURNAL NATURAL MEDICINES |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279770]  |
| 专题 | 天然药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 药理学第三研究室 |
| 通讯作者 | Ye Bo-Ping |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, China State Key Lab Drug Res, Shanghai 201203, Peoples R China; 2.Univ Jinan, Sch Biol Sci & Technol, Jinan 250022, Shandong, Peoples R China; 3.China Pharmaceut Univ, Sch Life Sci & Technol, Nanjing 210009, Jiangsu, Peoples R China; 4.Syngenta Jealotts Hill Int Res Ctr, Warfield RG42 6EY, Berks, England |
| 推荐引用方式 GB/T 7714 | Jiang Cheng-Shi,Zhou Zhen-Fang,Yang Xiao-Hong,et al. Antibacterial sorbicillin and diketopiperazines from the endogenous fungus Penicillium sp GD6 associated Chinese mangrove Bruguiera gymnorrhiza[J]. CHINESE JOURNAL OF NATURAL MEDICINES,2018,16(5):358-365. |
| APA | Jiang Cheng-Shi.,Zhou Zhen-Fang.,Yang Xiao-Hong.,Lan Le-Fu.,Gu Yu-Cheng.,...&Guo Yue-Wei.(2018).Antibacterial sorbicillin and diketopiperazines from the endogenous fungus Penicillium sp GD6 associated Chinese mangrove Bruguiera gymnorrhiza.CHINESE JOURNAL OF NATURAL MEDICINES,16(5),358-365. |
| MLA | Jiang Cheng-Shi,et al."Antibacterial sorbicillin and diketopiperazines from the endogenous fungus Penicillium sp GD6 associated Chinese mangrove Bruguiera gymnorrhiza".CHINESE JOURNAL OF NATURAL MEDICINES 16.5(2018):358-365. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。