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5,4 '-Dihydroxy-7,8-dimethoxyflavanone and Aliarin from Dodonaea viscosa Are Activators of PPAR gamma

文献类型：期刊论文

作者Zhu, Jing-jie1,3; Ji, Jun2; Hou, Ai-Jun2; Wang, He-Yao1
刊名PLANTA MEDICA
出版日期2018-05
卷号84期号:8页码:500-506
关键词Dodonaea viscosa Sapindaceae 5,4 ' dihydroxy-7,8-dime-thoxyflavanone aliarin diabetes mellitus adipogenesis partial PPAR gamma agonists
ISSN号0032-0943
DOI10.1055/s-0043-120270
文献子类Article
英文摘要PPAR gamma agonists are widely used medications in diabetes mellitus therapy. Their role in improving adipose tissue function contributes to antidiabetic effects. The extracts of Dodonaea viscosa have been reported to exert antidiabetic activity. However, the effective mediators and the underlying mechanisms were largely unknown. In this study, we investigated the action on PPAR. transactivation and adipocyte modulation of two typical flavonoid constituents from D. viscosa, 5,4'-dihydroxy- 7,8-dimethoxyflavanone and aliarin. Our results showed that 5,4'-dihydroxy-7,8-dimethoxyflavanone and aliarin were potential partial PPAR. agonists. The compounds induced adipogenesis in 3T3-L1 cells, with an upregulated adiponectin mRNA level and enhanced insulin sensitivity. The favorable effects of 5,4'-dihydroxy-7,8-dimethoxyflavanone, aliarin, and other flavonoid constituents on adipocytes might contribute to the antidiabetic efficacy of D. viscosa.
WOS关键词HIGH-FAT DIET ; RECEPTOR-GAMMA ; AERIAL PARTS ; ADIPOGENESIS ; MECHANISM ; AGONISTS ; OBESITY ; CELLS ; ADIPONECTIN ; BINDING
资助项目National Natural Science Foundation[81473262] ; National Natural Science Foundation[81503124] ; National Natural Science Foundation[81222045] ; National Natural Science Foundation[21372049] ; Science and Technology Commission of Shanghai Municipality Project[15431901000] ; Science and Technology Commission of Shanghai Municipality Project[14ZR1447700] ; State Key Laboratory of Drug Research[SIMM1705KF-05] ; Institutes for Drug Discovery and Development, Chinese Academy of Sciences[CASIMM0120162025] ; Institutes for Drug Discovery and Development, Chinese Academy of Sciences[CASIMM0120164014]
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine
语种英语
WOS记录号WOS:000433178600002
出版者GEORG THIEME VERLAG KG
源URL[http://119.78.100.183/handle/2S10ELR8/279771]  
专题药理学第三研究室
中科院受体结构与功能重点实验室
新药研究国家重点实验室
通讯作者Hou, Ai-Jun; Wang, He-Yao
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai, Peoples R China;
2.Fudan Univ, Sch Pharm, Dept Pharmacognosy, 826 Zhang Heng Rd, Shanghai 201203, Peoples R China;
3.Univ Chinese Acad Sci, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Zhu, Jing-jie,Ji, Jun,Hou, Ai-Jun,et al. 5,4 '-Dihydroxy-7,8-dimethoxyflavanone and Aliarin from Dodonaea viscosa Are Activators of PPAR gamma[J]. PLANTA MEDICA,2018,84(8):500-506.
APA Zhu, Jing-jie,Ji, Jun,Hou, Ai-Jun,&Wang, He-Yao.(2018).5,4 '-Dihydroxy-7,8-dimethoxyflavanone and Aliarin from Dodonaea viscosa Are Activators of PPAR gamma.PLANTA MEDICA,84(8),500-506.
MLA Zhu, Jing-jie,et al."5,4 '-Dihydroxy-7,8-dimethoxyflavanone and Aliarin from Dodonaea viscosa Are Activators of PPAR gamma".PLANTA MEDICA 84.8(2018):500-506.

入库方式： OAI收割

来源：上海药物研究所

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