Resin glycosides from the seeds of Ipomoea muricata and their multidrug resistance reversal activities
文献类型：期刊论文
| 作者 | Wang, Wen-qiong; Liu, Shan-shan; Song, Wei-bin; Li, Jun ; Xuan, Li-jiang
|
| 刊名 | PHYTOCHEMISTRY
 |
| 出版日期 | 2018-05 |
| 卷号 | 149页码:24-30 |
| 关键词 | Ipomoea muricata (convolvulaceae) Resin glycosides Multidrug resistance reversal activity |
| ISSN号 | 0031-9422 |
| DOI | 10.1016/j.phytochem.2018.01.020 |
| 文献子类 | Article |
| 英文摘要 | Resin glycosides represent an important chemotaxonomic marker of the Convolvulaceae family and possess multidrug resistance (MDR) reversal activity. In our recent study, nine previously undescribed resin glycosides, Calonyctins B-J, were isolated from the seeds of Ipomoea muricata. Their structures with the absolute configuration were established on the basis of comprehensive spectroscopic analysis and chemical methods. Among these, Calonyctins F-I possessed a skeleton in which the aglycone moiety and the oligosaccharide core were linked by a 3-hydroxy-2-methylbutanoic acid moiety to form a 25-membered macrocyclic structure. Calonyctins E, J, and muricatic acid C methyl ester were noncytotoxic but enhanced the cytotoxicity of vincristine by 2.5-407.1 fold at 25 mu M in KB/VCR cells. Calonyctin E was the most active one. (C) 2018 Elsevier Ltd. All rights reserved. |
| WOS关键词 | INHIBITORS |
| 资助项目 | State Key Laboratory of Drug Research[SIMM1601ZZ-03] ; National Natural Science Foundation of China[81473111] ; National Natural Science Foundation of China[21702219] ; China Postdoctoral Science Foundation[2016M600345] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Plant Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000430778200003 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279779]  |
| 专题 | 上海中药现代化研究中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Xuan, Li-jiang |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 501 Haike Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Wen-qiong,Liu, Shan-shan,Song, Wei-bin,et al. Resin glycosides from the seeds of Ipomoea muricata and their multidrug resistance reversal activities[J]. PHYTOCHEMISTRY,2018,149:24-30. |
| APA | Wang, Wen-qiong,Liu, Shan-shan,Song, Wei-bin,Li, Jun,&Xuan, Li-jiang.(2018).Resin glycosides from the seeds of Ipomoea muricata and their multidrug resistance reversal activities.PHYTOCHEMISTRY,149,24-30. |
| MLA | Wang, Wen-qiong,et al."Resin glycosides from the seeds of Ipomoea muricata and their multidrug resistance reversal activities".PHYTOCHEMISTRY 149(2018):24-30. |
入库方式： OAI收割
来源：上海药物研究所
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